摘要
目的:观察电针治疗脓毒症的疗效,并探讨其作用机制。方法:将50例患者随机分为电针组(26例)和常规组(24例)。两组均给予抗感染、抗休克、呼吸支持以及营养支持等治疗,不给予影响胃肠动力药物,电针组在此基础上接受电针治疗,穴取足三里、天枢、上巨虚、下巨虚。测定两组患者治疗前后尿乳果糖和甘露醇排泄率的比值(L/M)、血浆D-乳酸以及两组患者到达目标喂养的时间,并比较两组疗效。结果:经治疗3天后,电针组的L/M比值(0.083±0.020)和血浆D-乳酸(0.155±0.196)mmol/L较常规组(0.123±0.034)、(0.193±0.377)mmol/L明显下降(均P<0.05);电针组到达目标喂养的时间(93.69±27.58)h较常规组(118.17±40.28)h明显缩短(P<0.05)。电针组总有效率为80.8%(21/26),优于常规组的54.2%(13/24,P<0.05)。结论:在常规治疗的基础上加用电针,能改善脓毒症患者的肠道通透性,尽快地恢复肠道功能,早期实现目标喂养。
Objective To observe the efficacy of electroacupuncture on sepsis and explore its mechanism. Methods Fifty cases were randomized into an observation group （26 cases） and a control group （24 cases）. The therapeutic programs of anti-infection, anti-shock, respiratory support and nutritional support were provided, but the drugs that might affect gastrointestinal motility were not prescribed in two groups. In the observation group, on the basic treatment as above, electroacupuncture was applied to Zusanli （ST 36）, Tianshu （ST 25）, Shangjuxu （ST 37）, Xiajuxu （ST 39）. The excretion ratio of lactulose to mannitol （L/M） in urine and serum D-lactic acid level were detected before and after treatment, as well as the time of target feeding of the patients in two groups. The efficacy was compared between two groups. Results After treatment for 3 days, L/M was （0. 083±0. 020） and serum D-lactic acid was （0. 155-±0. 196） mmol/L in the observation group, which were apparently reduced as compared with （0. 123±0. 034） and （0. 193±0. 377） mmol/L in the control group respectively （both P〈0.05）. The time of target feeding was （93.69±27.58） h in the observation group, which was shortened apparently than （118.17±40.28） h in the control group （P〈0.05）. The total effective rate was 80.8o//oo （21/26） in the observa- tion group, which was better than 54.2% （13/24） in the control group （P^0.05）. Conclusion Conventional treatment combined with electroacupuncture can improve intestinal permeability in sepsis patients, recover intesti- nal function as quickly as possible to achieve target feeding.
出处
《中国针灸》
CAS
CSCD
北大核心
2013年第3期203-206,共4页
Chinese Acupuncture & Moxibustion
基金
浙江省中医药青年课题研究计划项目:2008YA 008
关键词
脓毒症
电针
乳果糖
甘露醇
D-乳酸
肠道通透性
目标喂养
sepsis
electroacupuncture
lactulose/mannitol （L/M）
D-lactic acid
intestinal permeability
tar-get feeding
