摘要
目的 观察联合使用一氧化氮 (NO)和腺苷 (AD)对肺动脉高压的影响。方法 选用上海种白猪 10头 ,建立急性缺氧性肺动脉高压模型 ,采用分别使用吸入NO 2 0× 10 -6和静脉持续每分钟滴注AD 5 0 μg/kg体重 ,以及联合使用NO和AD的方式 ,在各时段进行各项血流动力学指标测定。结果 联合使用NO和AD ,平均肺动脉压力从 (37± 7)mmHg(1mmHg =0 .133kPa)降至 (2 0± 1)mmHg(P <0 .0 1) ,心排指数从 (2 .30± 0 .5 0 )L·min-1·m-2 升至 (2 .76± 0 .46 )L·min-1·m-2 (P <0 .0 5 )。结论 NO和AD联合治疗幼猪急性缺氧性肺动脉高压 ,在降低肺动脉压力的同时 ,还可增加心输出量。
Objective\ To investigate the effects of the combined use of nitric oxide (NO) and adnosine (AD) on pulmonary hypertension. Methods\ Ten mechanically ventilated piglets with pulmonary hypertension induced by acute hypoxia were studied. Hemodynamic data were measured during the combined use of inhaled NO (20×10 -6 ) and constant intravenous infusion of AD (50 μg·kg -1 ·min -1 ). Results\ Combined use of inhaled NO and constant intravenous infusion of AD could significantly decrease mean pulmonary artery pressure (MPAP) from (37±7) mm Hg to (20±1) mm Hg (1 mm Hg=0.133 kPa) ( P <0.01) , and increase cardiac index (CI) from (2.30±0.50) L·min -1 ·m -2 to (2.76±0.46) L·min -1 ·m -2 ( P <0.05). Conclusion\ Combined use of inhaled NO and constant intravenous infusion of AD could decrease MPAP and increase CI in acute hypoxia induced pulmonary hypertension piglets.\;
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2000年第6期507-508,共2页
Chinese Journal of Experimental Surgery
