摘要
目的 :探讨抗心肌 β 肾上腺素能受体 (简称 β 受体 )抗体对小儿心脏病的诊断价值。 方法 :运用免疫印转法检测了 30例病毒性心肌炎 (VMC) ,14例扩张型心肌病 (DCM) ,2 2例先天性心脏病 (CHD) ,10例风湿性心脏病(RHD)患儿和 2 5例正常对照组 (NC)血浆抗 β 受体抗体水平。 结果 :VMC和DCM患儿中抗 β 受体抗体的阳性率显著高于CHD、RHD和NC组 (P <0 .0 1)。抗 β 受体抗体诊断VMC和DCM的灵敏度为 80 % ,特异度为 98%。 结论 :小儿心脏病的鉴别诊断中抗 β 受体抗体的测定有重要价值 。
Aim: In order to explore the diagnostic value of autoantibody against myocardiac β adrenoceptor (aiti β) in children with heart diseases. Methods: In this study,the plasma anti β levels of 5 groups (101 children) including viral myocarditis(VMC)group,dilated cardiomyopathy (DCM) group,congenital heart diseases (CHD) group,rheumatic heart diseases (RHD) group and normal control (NC) group were detected using western blot. Results: The plasma levels of anti β in VMC and DCM groups were significantly higher not only than that in NC group( P <0.01),but also than those in the CHD and RHD groups ( P <0.01).The diagnostic sensitivity and specificity of anti β for VMC and DCM were 80% and 98%respectively.Conclusion:The anti β has important value for differential diagnosis of children's heart diseases.It can be taken as a specific marker for dignosis of VMC and DCM in chlidren.
出处
《河南医科大学学报》
2000年第6期510-512,共3页
Journal of Henan Medical University
基金
河南省科技攻关基金资助项目!981170 5 14
关键词
儿童
病毒性心肌炎
β-肾上腺素能受体抗体
receptors,adrenergic beta
myocarditis
cardiomyopathy,congestive
antibodies
diagnosis,differential
chi
