摘要
目的探讨分析单纯低分子肝素加华法林抗凝疗法对次大面积肺栓塞的临床疗效,对次大面积肺栓塞的治疗有效性及安全性作进一步的评价。方法回顾性分析我院2010年1月至2012年2月收治的20例次大面积肺栓塞患者,入院后给予低分子量肝素钙进行皮下注射,0.1 mL/10 kg,q 12 h,同时加用华法林(初始剂量3 mg/d)。观察其治疗前后的心率、呼吸频率、血氧饱和度(SO2)、PO2、PCO2等变化及并发症情况。结果患者的心率、SO2等指标较治疗前显著改善,具有统计学意义(P<0.05);PO2分压显著增高、PCO2趋于正常,具有统计学意义(P<0.05);患者的肺动脉压显著降低;无严重出血等不良反应发生。结论单纯抗凝治疗对次大面积肺栓塞的疗效显著,而且是一种安全有效的方法,值得向临床推荐。
Objective Discussion and analysis of the simple low molecular weight heparin plus warfarin anticoagulation therapy on secondary pulmonary embolism clinical efficacy,A large area for the treatment of pulmonary embolism efficacy and safety for further e- valuation. Methods A retrospective analysis of our hospital in January 2010 to February 2012 treated 20 cases of massive pulmonary embolism patients, admitted after treated with low molecular weight heparin calcium subcutaneous injection of Q ,0.1 mL/10 kg, 12 h, plus warfarin（ initial dose 3 mg/d）. Observation before and after the treatment of heart rate, respiratory rate, oxygen saturation（ SO2 ）, PO2, PCO2 changes and complications. Results The heart rate of the patient,the SO2 index compared with those before treatment were significantly improved, with statistical significance, （P 〈 0.05 ） ; partial pressure of PO2 increased, PCO2 tends to normal, with statisti- cal significance （P 〈 0.05） ; patients with pulmonary arterial pressure significantly reduced; no severe bleeding and other adverse re- actions. Conclusion The simple anticoagulant therapy is a safe and effective method in sub - massive area pulmonary embolism, and it is worth to the clinical recommendations.
出处
《哈尔滨医药》
2013年第1期1-1,4,共2页
Harbin Medical Journal
关键词
抗凝治疗
次大面积肺栓塞
疗效
Anticoagulant therapy
Sub -massive area pulmonary embolism
Curative effect
