摘要
慢性便秘是最常见的胃肠功能紊乱症状之一,对患病人群的生活质量有着广泛的影响,在各国医疗支出中占比例高.便秘受多种肠道动力以及内分泌因素的影响.近年来,慢性便秘的药物治疗靶点趋向于肠肌层神经、神经传导介质及其受体改变、盆底肌和肛提肌收缩不协调等.本文搜集归纳国内外近年便秘治疗常用药,尤其是促结肠动力药物,包括无羟色胺(5-HT)受体激动剂、氯离子通道激活剂、尿鸟苷素和鸟苷酸环化酶-C受体激动剂、阿片拮抗剂等,就其疗效和安全性综述如下.
Chronic constipation （CC） is one of the most common functional gastroin testinal disorders. Possible etiologies for CC include alterations in gastrointestinal motility and secretion. Research efforts in CC have led to the identification of multifactorial and often overlapping etiologies including abnormalities in myenteric neurons, alterations in neurotransmitters and their recep- tors, and incoordination of the muscles of the pelvic floor or anorectum. In this article, we re- view the safety and efficacy of colonic motilitypromoting agents, such as 5-HT modulators,motilin agonists, chloride-channel activators, opioid antagonists, uroguanylin and GC-2C re- ceptor agonists, in the management of CC.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第5期434-439,共6页
World Chinese Journal of Digestology
基金
江苏省六大人才高峰重点课题基金资助项目
No.2011-WS40
江苏省中医药管理局课题基金资助项目
No.LZ11042~~
关键词
慢性便秘
促结肠动力药物
疗效
安全性
Chronic constipation
Colonic motility-promoting agents
Curative effect
Safety
