摘要
目的探讨聚腺苷二磷酸核糖聚合酶(PARP)表达与食管癌后程加速超分割放疗疗效的关系。方法采用免疫组化S-P法检测PARP表达,98例食管癌患者根据PARP表达情况分为4组:阴性常规组、阴性后超组、阳性常规组和阳性后超组。然后根据分组情况对患者进行常规分割放疗或后程加速超分割放疗。结果阴性常规组、阴性后超组、阳性常规组、阳性后超组的3 a局部控制率分别为57.7%、64.3%、35.0%、54.2%;3 a生存率分别为34.6%、46.4%、10.0%、29.2%。结论 PARP表达阳性者预后差,后程加速超分割放疗并未较常规分割放疗提高疗效。
Objective To investigate the relationship between the poly ADP-ribose polymerase （PARP） expression and the efficacy of late course accelerated hyperfractionated radiotherapy on esophageal carcinoma. Methods The PARP expressions of 98 patients with esophageal carcinoma were detected with immunohistochemistry S-P method,the 98 patients were divided into four groups： the PARP negative conventional radiotherapy group, the PARP negative late course accelerated hyperfractionated radiotherapy group, the PARP positive conventional radiotherapy group, the PARP positive late course accelerated hyperfractionated radiotherapy group. The conventional radiotherapy or late course accelerated hyperfractionated radiotherapy was given to the patients accorded to the grouping situation.Results In the PARP negative conventional radiotherapy group, the PARP negative late course accelerated hyper- fractionated radiotherapy group, the PARP positive conventional radiotherapy group, the PARP positive late course accelerated hyperfractionated radiotherapy group, the 3-year local control rates were 57.7%, 64.3%, 35.0%, 54.2% , respectively; the 3-year survival rates were 34.6% ,46.4% , 10.0%, 29.2% , respectively. Conclusion The prognoses of patients with PARP positive are poor,compared with the conventional radiotherapy,the late course accelerated hyperfraetionated radiotherapy did not improve the survival in the patients with PARP positive.
出处
《肿瘤基础与临床》
2013年第1期31-33,共3页
journal of basic and clinical oncology
关键词
食管癌
后程加速超分割放疗
聚腺苷二磷酸核糖聚合酶
预后
esophageal carcinoma
late course accelerated hyperfractionated radiotherapy
poly ADP-ribose pol- ymerase
prognoses
