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脂肪乳剂救治局麻药全身毒性反应的作用及其应用前景 被引量：3

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摘要 区域神经阻滞麻醉数量逐年增多，而局麻药全身毒性（10calanestheticsystemictoxicity，LAST）为其严重的并发症之一。脂肪乳剂（1ipidemulsion，LE）用于LAST的救治具有里程碑意义，亦为脂溶性药物或毒物解毒治疗的开创之举.其作用与地位可与恶性高热特效治疗药物丹曲林相比拟。
作者 徐世元 张鸿飞
机构地区 南方医科大学珠江医院麻醉科 兰州大学第二医院麻醉科
出处 《国际麻醉学与复苏杂志》 CAS 2013年第3期193-197,共5页 International Journal of Anesthesiology and Resuscitation
关键词 全身毒性反应 脂肪乳剂 局麻药 救治 应用 神经阻滞麻醉 脂溶性药物 治疗药物
分类号 R614 [医药卫生—麻醉学]
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参考文献41

  • 1Brull SJ. Lipid emulsion for the treatment of local anesthetic toxicity: patient safety implications. Anesth Analg, 2008, 106 (5) : 1337-1339.
  • 2Weinberg GL. Lipid infusion resuscitation for local anesthetic toxicity: proof of clinical efficacy. Anesthesiology, 2006, 105 ( 1 ) : 7-8.
  • 3Weinberg GL, VadeBoncouer T, Ramaraju GA, et al. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine- induced asystole in rats. Anesthesiology, 1998, 88 (4): 1071-1075.
  • 4Rosenblatt MA, Abel M, Fischer GW, et al. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology, 2006, 105( 1 ) : 217-218.
  • 5Driscoll DF. Lipid injectable emulsions: 2006. Nutr Clin Pract, 2006, 21(4): 381-386.
  • 6张鸿飞,徐世元.脂肪乳用于长效局麻药中毒的救治[J].国际麻醉学与复苏杂志,2009,30(6):541-543. 被引量：5
  • 7Corcoran W, Butterworth J, Weller RS, et al. Local anesthetic- induced cardiac toxicity: a survey of contemporary practice strategies among academic anesthesiology departments. Anesth Analg, 2006, 103(5): 1322-1326.
  • 8Williamson RM, Haines J. Availability of lipid emulsion in obstetric anaesthesia in the UK: a national questionnaire survey. Anaesthesia, 2008, 63(4): 385-388.
  • 9Pieard J, Ward SC, Zumpe R, et al. Guidelines and the adoption of "lipid rescue" therapy for local anaesthetic toxicity. Anaesthesia, 2009, 64(2): 122-125.
  • 10Harvey M, Cave G. Survey of the availability of lipid emulsion infusion in Australasian emergency departments. Emerg Med Australas, 2008, 20(6): 531-533.

二级参考文献39

  • 1张新建,徐世元,周健,张鸿飞,梁启波,张庆国.性别对腹部手术病人罗库溴铵肌松作用的影响[J].中华麻醉学杂志,2006,26(4):296-298. 被引量：23
  • 2Weinberg GL, VadeBoncouer T, Ramaraju GA, et al. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology, 1998, 88 (4): 1071-1075.
  • 3Weinberg GL, Ripper R, Feinstein DL, et al. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med, 2003, 28(3): 198-202.
  • 4Weinberg GL, Ripper R, Murphy P, et al. Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med, 2006, 31 (4): 296-303.
  • 5Weinberg GL, Di Gregorio G, Ripper R, et al. Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology, 2008, 108(5) : 907-913.
  • 6Di Gregorio G, Schwartz D, Ripper R, et al. Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin- induced cardiac arrest. Crit Care Med, 2009, 37(3): 993-999.
  • 7Mazoit JX, Le Guen R, Beloeil H, et al. Binding of long-lasting local anesthetics to lipid emulsions. Anesthesiology, 2009, 110 (2) : 380-386.
  • 8Mayr VD, Mitterschiffthaler L, Neurauter A, et al. A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine. Anesth Analg, 2008, 106 ( 5 ) : 1566 - 1571.
  • 9Weinberg GL. Lipid infusion therapy: Translation to clinical practice. Anesth Analg, 2008, 106(5): 1340-1342.
  • 10Eledjam JJ, de La Coussaye JE, Brugada J, et al. In vitro study on mechanisms of bupivacaine-induced depression of myocardial contractility. Anesth Analg, 1989, 69(6): 732-735.

共引文献5

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国际麻醉学与复苏杂志
2013年 第3期

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