摘要
目的探讨氯米帕明的不良反应/事件,为临床安全用药提供参考。方法对精神疾病杂志和相关药学杂志近15年刊登的有关氯米帕明药品不良反应的病例报告和我院监测搜集的病例进行统计分析。结果发现氯米帕明的不良反应/事件包括9大类25种临床表现,以癫痫发作、白细胞减少、肝功损害、精神障碍多见。新的不良反应有精神障碍、锥体外系反应、过敏、白细胞减少、发热、依赖等。62.75%在15天内出现不良反应。结论氯米帕明的不良反应较严重,要注意防范。
Objective To investigate adverse reactions of clomipramine provide a reference for chnical safety of drugs. Methods To analyze the case reports of adverse reactions of clomipramine published by mental journals and pharmaceutical journals in the past 15 years, and several cases collected at our hospital. Results Clomipramine adverse reactions involve 9 major categories including 25 kinds of clinical manifestations, most of them are seizures, leukopenia, hver damage and mental disorders. Newly discovered adverse reactions are mental disorders, extrapyramidal reactions, allergies, leukopenia, fever, dependence, etc. 62.75% adverse reaction occurred within 15 days. Conclusion Adverse reactions of clomipramine are more serious, should pay. attention to prevention.
出处
《中国药物警戒》
2013年第2期101-103,共3页
Chinese Journal of Pharmacovigilance
