摘要
目的 观察内皮素 1(endothelin 1,ET 1)在人口腔粘膜下纤维化 (oralsubmucousfibrosis,OSF)组织中的形态学定位 ,并探讨ET 1与OSF病变的关系。方法 用免疫电镜技术检测ET 1在OSF组织中的超微结构定位。结果 ET 1免疫阳性颗粒主要存在于OSF组织的上皮细胞、成纤维细胞及内皮细胞的胞浆内。正常口腔粘膜组织中未发现ET 1免疫阳性颗粒。OSF组织中 ,上皮细胞内的ET 1阳性颗粒定位于细胞膜上 ,胞浆内的阳性颗粒可能定位于粗面内质网、线粒体上 ,成纤维细胞内的阳性颗粒定位于线粒体、粗面内质网和细胞膜上。内皮细胞内的阳性颗粒较少。结论 ET
Objective To determine the endothelin 1 ( ET 1)immunoreactivity in biopsies from human oral submucous fibrosis (OSF)and to investigate the relation between ET 1 and OSF Methods The localization of ET 1 in biopsies from OSF was observed with immunoelectron microscopic techniques Results High density deposits existed predominantly in the cytoplasm of epithelial cells, fibroblasts and endothelial cells, but not found in the biopsies of normal controls In the biopsies of OSF, high density granules were lined on the cell membrane ,possibly on the rough endoplsamic reticulum and the mitochondria of the epithelial cells and of the fibroblasts But a few granules were seen in the cytoplasm of the endothelial cells of microvesseles Conclusion ET 1 is one of the pathogenetic factors of OSF
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2000年第3期215-217,I016,共4页
Chinese Journal of Stomatology
基金
湖南省科委发展基金!( 99ssy2 0 0 2 14 )
