摘要
目的 探讨酒精性肝病 (ALD)的超微结构特点及其与肝功能损害程度的关系。方法 对 2 0例高原藏族ALD患者行肝穿活检组织病理学观察。结果 酒精性脂肪肝 (AFL)、酒精性肝炎 (AH)、酒精性肝硬化 (ALC)常相继发生或同时存在 ,主要表现为肝细胞大泡性脂变 ,窦周纤维化 ,肝细胞滑面内质网增生 ,小叶内灶状坏死伴中性粒细胞浸润。无论肝超微结构改变轻重 ,均有不同程度的肝功能异常 ,尤其在A/G≤ 1的患者 ,上述改变较重。结论 贮脂细胞的活化状态直接影响到肝病进程及肝功能异常程度。
Objective To investigate the ultastructural characteristics of alcoholic liver disease (ALD) and the relationship between ALD and the degree of liver functional damage. Methods Liver tissues obtained by puncture biopsy were examined in 20 cases of Tibetan ALDs. Results Alcoholic fatty degeneration, alcoholic hepatitis and alcohonic liver cirrhosis always co-existed or occurred consequentially. The main pathologic changes were a focal ballooning fatty degeneration, perisinuous fibrosis and hyperplasia of smooth endoplasmic reticulum of liver cells, and focal necrosis with neutrophilic granulocyte infiltration. No matter what degree of liver damage was liver function was always abnormal, especially more severe in the patient whose A/G ratio was less 1. Conclusion The activation of fat-storing cells will directly effects on the consequence of the liver disease and the degree of liver functional damage. Other factors which involve in ALDs were also discussed.
出处
《诊断病理学杂志》
CSCD
2000年第2期110-111,I025,共3页
Chinese Journal of Diagnostic Pathology
关键词
酒精性肝病
超微结构
临床病理
电镜
Tibetan Plateau Alcoholic liver disease Ultrastructure
