摘要
纳米颗粒具有高的安全性、良好的生物相容性、易于生产、可以运载不同大小的DNA片段,保护DNA免受核酸酶的降解作用,纳米颗粒在生物体及细胞内具有较高的稳定性,不易被降解等优点,利用纳米颗粒作为基因载体可以提高转染效率。纳米颗粒作为非病毒载体在基因治疗上的应用成为研究热点。介绍纳米材料的性质,纳米基因载体的特点和转运机制,以及纳米基因载体的研究进展。
Nanoparticles have some characteristics such as can combine with big fragment DNA, low immunogenic, good biocompatibility, easy to produce, which can protect DNA against the digestion of nuclease. The nanoparticles have a high stability in organisms and ceils, which was difficult to be degraded. Nanoparticles can improve transfection efficiency. As a nonviral gone vector, the application of nanoparticles in gone therapy became research focus. In this article, we mainly discussed the characteristics of nanoparticles, characteristics and transport mechanism of nanoparticles as gene vector, the progress on nanoparticles as zone vector.
出处
《生物技术通报》
CAS
CSCD
北大核心
2013年第2期61-66,共6页
Biotechnology Bulletin
基金
转基因生物新品种培育科技重大专项资助项目(2009ZX08010-006)
关键词
纳米材料
基因载体
转染
Nanoparticles Gene vectors Transfection
