摘要
目的 探讨前列腺间质肉瘤的临床病理特征。方法对两例该肿瘤作常规ＨＥ染色及免疫组织化学标记，在光镜下观察组织学形态及免疫组化表达。结果前列腺间质肉瘤是发生于前列腺特异性间质细胞的肿瘤。发病高峰在老年人（５０～６９岁）。镜下肿瘤组织以间质细胞高度增生伴中－高度异型为特征。病变内可含良性前列腺腺体成分，类似于乳腺的叶状囊肉瘤。免疫组化表达Ｖｉｍｅｎｔｉｎ，ＣＤ３４及ＰＲ阳性。结论 前列腺间质肉瘤是一种在组织学特征及免疫组化表型上都不同于其他间叶性肿瘤的激素依赖性肿瘤。激素治疗有效。应将其作为一种独立的肿瘤诊断。
Objective To study the clinical pathological characterisites and the diagnosis of prostatic stromal sarcoma (PSS). Methods The clinicopathologic features and immnunohistochemical profile of 2 cases of PSS were studied. Results PSS originated in specialized prostatic stroma. It occurred in males above 60 years old. The histologic features of PSS were characterized by highly proliferative specialized prostatic stroma with moderate to high degree of cytological atypia, and associated with non-neoplastic prostatic glandular elements. Immunohistochemical staining of Vimentin, CD34 and PR were positive. conclusions The histologic features and immunohistochemical profile of PSS are different from other mesenchymal lesions of the prostate. It is a hormonal responsive tumor, which originates from prostatic specialized stroma. [
出处
《老年医学与保健》
CAS
2000年第2期70-71,85,F002,共4页
Geriatrics & Health Care
关键词
前列腺间质肉瘤
病理诊断
免疫组化
Prostatic stromal sarcoma
Pathologic diagnosis
Immunohistochemistry - CD34
