摘要
目的 了解内毒素、细胞因子、一氧化氮在门脉高压症发生高动力循环综合征中所起的作用。方法 综述了近 10年来国外对门脉高压症发生高动力循环综合征的研究和认识。结果 所有门脉高压动物模型及 30 %～ 5 0 %的肝硬变患者均存在高动力循环综合征。内毒素、细胞因子、一氧化氮在高动力循环综合征形成中所起作用的研究结果还不一致。结论 是高动力循环综合征维持和加剧了门脉高压。内毒素、细胞因子、一氧化氮在高动力循环综合征发生中可能起作用 ,其中一氧化氮较为重要 。
Objective The effects of endotoxin, cytokines, nitric oxide were reviewed in the development of hyperdynamic circulatory syndrome in portal hypertension. Methods Liceratures of overseas main studies in hyperdynamic circulatory syndrome of portal hypertension in recent 10 years were reviewed. Results The hyperdynamic circulatory syndrome was found in 30%-50% of patients with cirrhosis and in all animal models of portal hypertension. The research results of the effects of endotoxin, cytokines, nitric oxide in the development of hyperdynamic circulatory syndrome were different. [WT5”HZ]Conclusion [WT5”BZ]Hyperdynamic circulatory syndrome contribute to the maintenance and aggregation of portal hypertension. Endotoxin, cytokines, nitric oxide may play a role in the development of hyperdynamic circulatory syndrome. Nitric oxide is a more important factor. The effect of other factors is probably mediated by nitric oxide.
出处
《中国普外基础与临床杂志》
CAS
2000年第4期275-276,F003,共3页
Chinese Journal of Bases and Clinics In General Surgery
