摘要
目的探讨皮肤侵袭性鳞状细胞癌(SSCC)的临床表现及组织病理特征的相关性。方法回顾性分析84例临床及组织病理资料齐全的侵袭性SSCC患者的临床资料,以30例正常皮肤组织为对照组,分析其临床表现及组织病理类型特征。结果 84例患者中,病灶为溃疡型20例(23.8%)、结节隆起型46例(54.8%)、浸润型16例(19.0%)、萎缩型2例(2.4%);暴露部位为头面部51例(60.7%)、会阴部20例(23.8%)、躯干部13例(15.5%)。组织病理类型中寻常型52例(61.9%)、疣状型14例(16.7%)、基底细胞样型12例(14.3%)、尖锐湿疣型6例(7.1%);病灶周边区域表皮病变中轻度上皮内瘤变31例(36.9%)、鳞状上皮增生27例(32.1%)、中重度上皮内瘤变26例(31.0%)。与对照组相比,SSCC患者病灶组织p16蛋白阳性表达较低,而pRb蛋白表达较高(P<0.05)。结论 SSCC临床上以头面部及结节隆起型最常见,组织病理类型以寻常型常见,应用免疫组织化学技术有助于诊断。
Objective To investigate the clinical and pathological features of invasive skin squa- mous cell carcinoma （ SSCC）. Methods Atotal of 84 patients with SSCC confirmed by clinical and pathological diagnosis were collected to retrospective analyze, and the 30 normal people were collected to control group. The clinical and pathological features were analyzed. Results Among the 84 cases, 20 cases （23.8%） were ulcer, 46 cases （54.8%） were tubercle apophysis, 16 cases （ 19.0% ） were infiltration, 2 cases （2.4%） were atrophy. And the tumors of 51 （60.7%） cases were taken place at maxillofacial region, 20 cases （23.8%） at perineal region, 13 cases （ 15.5% ） at trunk re- gion. Four histopathology types were included： common （ 61.9% ） , verrucous （ 16.7% ） , basaloid （14.3%） , condylomatous （7. 1% ）. The morphologic features of adjacent epidermal lesions were as followed ： low-grade squamous intraepithelial lesion （ 36.9 % ）, squamous hyperplasia （ 32. 1% ）, mod- erate/ high-grade squamous intraepithelial lesion（31.0% ）. The expression levels of p16 was lower than control group （P 〈 0.05 ）, whereas pRb was higher than control group （ P 〈 0. 05 ）. Conclusions The most frequent clinical manifestation was tubercle apophysis, and the predominant pathological type was com- mon type in invasive SSCC located on the maxillofacial region. The application of immunohistochemistry technique could be help to diagnosis.
出处
《中国肿瘤临床与康复》
2013年第2期163-165,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
皮肤鳞状细胞癌
侵袭性
组织病理
免疫组化
临床表现
Skin squamous cell carcinoma
Invasive
Histopathology
Immunohistochemis- try
Clinical features
