摘要
本文对120名HBV血清标记均阴性的健康人群,随机分皮下组和皮内组。两组在年龄、性别比例均衡。试验结果:皮下组和皮内组在3针免疫后随访3年观察,抗-HBs阳转率和抗体P/N均值分别为98.4％,98.3％;98.2％,98.1％;93.0％,95.8％;88.0％对89.4;59.5对58.3;50.4对43.6;P>0.05。疫苗接种者无严重不良反应。表明皮内组可获得与皮下组相似的免疫效果。
120 seronegstive healthy persons received the inoculation of hepatitis B vaccine were randomly divided into subcutaneous group (Ⅰ) and intradermal group (Ⅱ). The proportions of the age groups and the sexes had no significant differences in the two groups. After the third injections, through three years observation the results revealed that the anti-HBs seroconversion rates and P/N ratios of the two groups were 98.4%, 98.3%; 98.2%; 98.1%; 93.0%, 95.0%; and88.0, 89.4; 59.5, 58.3; 50.4, 43.6; respectively (P>0.05). No serions side effect was shown in all the persons vaccinated. It shows that the two groups have similar immunogenic effect.
出处
《北京医学》
CAS
北大核心
1991年第1期3-5,共3页
Beijing Medical Journal
