摘要
目的探讨中重度子宫内膜异位症腹腔镜保守性手术治疗后应用戈舍瑞林、米非司酮治疗的临床疗效及不良反应。方法选择经腹腔镜保守手术后确诊的中重度子宫内膜异位症患者68例，随机区组法分为戈舍瑞林组34例、米非司酮组34例，疗程6个月，定期随访。比较两组临床疗效及不良反应。结果两组患者痛经症状均得到不同程度缓解，有效率均91％以上，复发率米非司酮组高于戈舍瑞林组（14．71％与2．94％，P〈0．05），停药1年内累计妊娠率米非司酮组低于戈舍瑞林组（20．59％与38．23％，P〈0．05）；戈舍瑞林组肝功能损害发生率低于米非司酮组（2．94％与23．53％，P〈0．05）。结论中重度子宫内膜异位症腹腔镜保守性手术治疗后加用抑制卵巢功能药物对提高妊娠率、降低复发率有重要意义。、
Objective To investigate the effect and severe adverse reactions of goserelin combined with mife- pristone after operation for moderate and endometriosis laparoscopic conservative. Methods 68 cases with moderate to severe endometriosis diagnosed after laparoscopic conservative operation were randomly divided into the Gore Sherry Lin group and mifepristone group with 34 cases for 6 months of a course, regular follow-up. Clinical efficacy and ad- verse reaction for two groups were compared. Results The dysmenorrhea symptoms for two groups of patients have been alleviated, the efficiency rate was above 91%. The recurrence rate of the mifepristone group was higher than the goserelin group （ 14.71% vs 2.94%, P 〈 0.05 ）. The cumulative pregnancy rate of mifepristone group was lower than the goserelin group （20.59% vs 38.23 %, P 〈 0.05 ） discontinued for 1 years. The liver function damage of the gose- relin group was significantly lower than the mifepristone group （2.94% vs 23.53%, P 〈 0. 05 ）. Conclusion It is more significance for using suppression of ovarian function after laparoscopic conservative operation for severe endome- triosis. It can increase the pregnancy rate and decrease the recurrence rate.
出处
《中国基层医药》
CAS
2013年第3期375-377,共3页
Chinese Journal of Primary Medicine and Pharmacy
