摘要
本文用^(60)CO-γ线对受孕第九天大鼠一次性全身照射,观察致畸胎效应。剂量分组为0.OGy、0.5Gy和1.0Gy。结果表明:1.0 Gy组出现死胎率增加,生长发育迟缓以及露脑、腹壁裂、唇腭裂、无尾、短尾、脑积水、无眼、小眼等畸形,骨化不全率显著增高;0.5 Gy组也有一定程度的致畸胎效应。本文还报道了胎鼠脑和肝中的cAMP值,为探讨辐射致胚胎效应的机理提供依据。
The pregnant Wistar rats were exposed to 0.5 Gy and 1.0 GY ^(60)Co γ-rays at the 9th dayafter conception. The results: ^(60)Co γ-rays at dose of 1.0 Gy could induce many defects: excenphaly,hydrocephalus, gastroschisis, cleft palate and cleft lip, anophthalmia, microphthalmia, shorten tail andabsent tail in surviving fetuses. The growth retardation was found from the parameters of fetalweight, height, head circle and development of skeleton. In the group of radiation dose 0.5 Gy,only hydrocephalus, absent tail and growth retardation of skeleton appeared. The results suggest thatlow-dose exposure in the early pregnant rats can induce fetal defects and growth retardation. Theprobable mechanism of teratogen and growth retardation was discussed. The cAMP levels of brain andliver of rat fetuses were reported.
出处
《北京医科大学学报》
CSCD
1991年第1期19-21,共3页
Journal of Peking University(Health Sciences)
