摘要
以丙三醇为电解液体系制备出高有序的TiO2纳米管,通过模拟人体体液(SBF)溶液浸泡和体外细胞实验探讨不同尺寸TiO2纳米管生物活性的差异。利用扫描电子显微镜(SEM)、X射线衍射(XRD)等对样品进行表征。结果表明,相同电压下,随着阳极氧化电压的增加,TiO2纳米管管长和管径呈增加趋势。通过羟基磷灰石(HA)的沉积情况、MG-63细胞粘附情况、MTT检测分析,可以得出,随TiO2纳米管管长和管径的增加,诱导HA沉积能力和促进细胞粘附增殖能力增强,表现出较好的生物活性。
High order TiO2 nanotubes was prepared in glycerol solution as electrolyte by anodic oxidation.The differences of biological activity were studied of the different sizes of TiO2 nanotubes.The samples were soaked in simulated body fluid（SBF） to observe the deposition of hydroxyapatite and explored the biocompatibility by cell cytotoxicity experiments in vitro.Experimental results showed TiO2 nanotubes had different diameter and tube length under different anodic oxidation voltage.With anodizing voltage increasing the nanotubes showed increasing wall and diameter.The samples were characterized by scanning electron microscopy（SEM）,X-ray diffraction（XRD）,etc.Hydrophilicity deposition,MG63 cell adhesion,and other biological evaluation were observed.The conclusion showed the samples showed the better biological activity with the increasing nanotube length and diameter of TiO2 nanotubes.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2013年第4期517-521,526,共6页
Journal of Functional Materials
基金
国家重大科学研究计划资助项目(2012CB933902)
新世纪优秀人才支持计划资助项目(NCET-09-0110)
中央级公益性科研院所基本科研业务费专项资金资助项目(1630032012032)
海南大学青年基金资助项目(qnjj1163)
