摘要
目的回顾性分析单纯化疗、全肺放疗联合化疗治疗鼻咽癌放疗后多发肺转移患者的治疗效果,探讨较为合理的治疗方案。方法分析46例鼻咽癌放疗后多发肺转移患者的治疗方式及不同治疗方式对治疗效果的影响,其中单纯化疗27例,全肺放疗联合化疗19例,化疗方案主要是:顺铂加5-氟尿嘧啶、紫杉醇加顺铂;全肺放疗单次剂量120～150cGy,总剂量(DT)1 800～2 100cGy,均是未校正剂量。结果单纯化疗组与全肺放疗联合化疗组的有效率分别是44.44%和73.68%(P<0.05);单纯化疗组和全肺放疗联合化疗组6、12、18个月生存率分别是81.48%、29.63%、7.41%和89.47%、63.16%、42.11%,其中12个月和18个月生存率两组比较差异有显著性(P<0.05)。结论全肺放疗联合化疗治疗鼻咽癌多发肺转移的治疗效果优于单纯化疗。
Objective therapy plus chemotherapy To retrospectively analyze the efficacy of chemotherapy alone, whole lung radio in the treatment of multiple lung metastasis after radiotherapy for patients with na sopharyngeal carcinoma, and to explore more reasonable treatment options. Methods 46 patients with mul tiple lung metastasis by nasopharyngeal carcinoma after radiotherapy were treated with different regimen in our hospital, the response rates of different regimen were assayed. Of which 27 cases received chemotherapy alone, 19 were given whole lung radiotherapy plus chemotherapy, the main chemotherapy regimen was- cisplatin plus 5--fluorouracil, paclitaxel plus cisplatin; single dosage of whole lung radiotherapy was 120% 150cGy, total dosage （DT） 1800-2100cGy, all were uncorrected dosages. Results The radiotherapy plus chemotherapy for the lung metastasis had much better response rate than chemotherapy （73. 68% vs. 44.44%, P 〈0.05）. The 6--month, 12--month, and 18--month survival rates of chemotherapy alone and radiotherapy plus chem- otherapy were 81. 48%.29. 63%.7.41% and 89. 47%.63. 16%.42. 11%, respectively. Compared the 12- month and 18--month survival rates of chemotherapy alone to radiotherapy plus chemotherapy, there were sta- tistically significant （ P 〈0.05）. lung metastasis of nasopharyngeal Conclusion Radiotherapy plus chemotherapy in the treatment of multiple carcinoma is better than chemotherapy.
出处
《右江民族医学院学报》
2013年第1期14-15,共2页
Journal of Youjiang Medical University for Nationalities
关键词
鼻咽肿瘤
肺转移
放射疗法
鼻咽肿瘤
肺转移
药物疗法
预后
nasopharyngeal neoplasms, lung metastasis/radiotherapy
nasopharyngeal neoplasms, lungmetastasis/ drug therapy
prognosis
