摘要
巨噬细胞是人免疫缺陷病毒(HIV)的宿主,藏匿在巨噬细胞中的HIV能在适宜时机复制而导致艾滋病复发,因此,巨噬细胞可成为HIV的新传染源。目前大部分抗艾滋病药的细胞膜渗透性差、体内半衰期短,造成给药剂量大和次数频繁,并且难以在巨噬细胞内分布而清除残留HIV。因此抗HIV巨噬细胞靶向给药系统的研究很重要。本文综述了抗HIV药物的纳米给药系统及其巨噬细胞靶向作用,涉及纳米粒、脂质体、纳米混悬剂、自组装药物传递系统、纳米凝胶和纳米囊,为艾滋病治疗提供新思路。
Macrophages are the reservoir of human immunodeficiency virus（HIV）.HIV hidden in the macrophages is replicated under appropriate conditions,leading to recurrence of AIDS.Macrophages are a new infection resource of HIV.Biomembrane penetration of current anti-HIV drugs is poor and the in vivo half life is short,resulting in high dose and frequent administration.Their distribution in macrophages is too little to eradicate the hidden HIV.Therefore,the development of anti-HIV macrophage-targeted delivery systems is very important.The review summarizes the nanoparticulate delivery systems of anti-HIV agents and their macrophage-targeted effects,involving nanoparticles,liposomes,nanosuspensions,self-assembled drug delivery systems,nanogels and nanocapsules,in order to provide a new strategy for the treatment of AIDS.
出处
《国际药学研究杂志》
CAS
CSCD
2013年第1期39-42,共4页
Journal of International Pharmaceutical Research
基金
国家科技重大专项"重大新药创制"候选药物(2012ZX09103101-059)
国家科技重大专项"重大新药创制"综合性新药研究开发技术大平台(2012ZX09301003-001-009)
