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不同尿白蛋白排泄率的2型糖尿病患者与外周动脉疾病相关性分析

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摘要 目的探讨不同尿白蛋白排泄率(UAER)的2型糖尿病患者合并外周动脉疾病(PAD)的发生情况及两者相关性。方法依据UAER将275例2型糖尿病患者分为对照组(UAER〈2μg/min,83例)、微量蛋白尿组(UAER20~200μg/min,102例)和临床蛋白尿组(UAER〉200μg/min,90例),检测所有患者的UAER、糖化血红蛋白(HbA1c)和踝肱指数,并分析各组患者PAD发生率、踝肱指数与UAER及其他指标的相关性。结果微量蛋白尿组和临床蛋白尿组PAD发生率分别为27.45%(28/102)、35.56%(32/90),均高于对照组的13.25%(11/83),差异有统计学意义(P〈0.05)。踝肱指数随UAER的增加而减低(P〈0.05),PAD发生率随UAER的增加而升高(P〈0.05);踝肱指数与病程、年龄、UAER呈负相关(r=-0.168、-0.360、-0.205,P〈0.05),与HbA1c无明显相关性(r=-0.087,P〉0.05)。结论2型糖尿病患者尿微量白蛋白不仅是肾脏病变的表现,同时伴有PAD发生率的增高,是全身血管病变的标志。
出处 《中国医师进修杂志》 2013年第4期61-62,共2页 Chinese Journal of Postgraduates of Medicine
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