摘要
血尿酸(SUA)是嘌呤代谢的终末产物,2/3由肾脏排泄。尿酸生成增多或排泄减少均可引起高尿酸血症(HUA)。既往认为高尿酸血症对人体的影响主要是尿酸盐沉积在关节腔及肾脏,引起相应病变。近期许多研究表明高尿酸血症与糖尿病的发生、发展密切相关,可作为2型糖尿病(T2DM)患者肾脏病变进展的一个独立危险因素。本文就对血尿酸水平与糖尿病肾病(DN)之间的相互关系做一综述。
Serum uric acid （SUA） is an end product of purine metabolism and two-third is excreted by the kidneys. Both increased generation and decreased excretion of uric acid can cause hyperuricemia （HUA）. As we all know, the main effect of hyperuricemia is that uric acid salt deposits in articular cavity and kidney, causing the corresponding lesions. Recently, many studies find that hyperuricemia is closely related with the progression of diabetes mcllitus. Hyperuricemia is an independent risk factor resulting in kidney disfunction in patients with type 2 diabetes mellitus （T2DM）. The present paper aims to review the relationship among the level of serum uric acid, the disorder of glycometabolic and diabetic nephropathy （DN） in patients with type 2 diabetes mellitus.
出处
《海南医学》
CAS
2013年第4期576-578,共3页
Hainan Medical Journal
关键词
2型糖尿病
血清尿酸
糖代谢紊乱
糖尿病肾病
Type 2 diabetes mellitus
Serum uric acid
Glycometabolic disorder
Diabetic nephropathy
