摘要
目的筛选健康参考个体，进行血清总胆红素和直接胆红素的检测，为建立适合本地区人群的血清胆红素参考区间提供参考。方法2009年10月至12月本院体检人群通过调查问卷及实验室检查排除肝胆疾病及代谢性疾病，共选取314例。应用两个不同的检测体系进行血清总胆红素和直接胆红素的检测。以性别分组计算参考区间，并与现行参考区间进行比较。结果不同性别间总胆红素水平差异有统计学意义（P〈0．01），两种不同检测体系测量值差异有统计学意义（P〈0．01）。应用Roche试剂，血清总胆红素参考区间为男性7．1～27．2μmol／L，女性4．8～20．9μmol／L，直接胆红素参考区间为男性1．4～6．8μmol／L，女性0．9～5．7μmol／L；应用Prodia试剂，血清总胆红素参考区间为男性9．5～35．7μmol／L，女性6．8～28．9μmol／L，直接胆红素参考区间为男性1．3～7．0μmol／L，女性1．0～6．6μmol／L。结论健康体检人群总胆红素和直接胆红素水平高于现行的参考区间，应修订现行胆红素参考区间，建立各地区、不同性别各自的参考区间。
Objective To select health individual and test serum total bilirubin and direct bilirubin in order to provide a reference range for the establishment of appropriate reference interval in this region. Methods From October to December in 2009, 314 of physical examination population of Beijing Hospital were selected by questionnaire and laboratory test excluding liver and gaUbladder diseases or metabolic diseases. Roche and Prodia reagents were used to test TBIL and DBIL, respectively. Reference interval was calculated by sex group and compared with the existing reference interval. Results The level of TBIL had a significant difference between different genders（ P 〈 0.01 ）. The level of TBIL had a significant difference between two kinds of reagents（ P 〈0. 01 ）. Using Roche reagent, the reference interval of TBIL was 7. 1 ～ 27. 2 μmoL/L for man, and 4. 8 ～ 20. 9 μmoL/L for woman, and the reference interval of DBIL was 1.4 ～ 6. 8 μmol/L for man, and O. 9 ～ 5.7 μmoL/L for woman. Using Prodia reagent, the reference interval of TBIL was 9. 5 ～ 35.7 μmol/L for man, and 6. 8 ～ 28. 9 μmol/L for woman, and the reference interval of DBIL was 1.3 ～ 7. 0 μmol/L for man, and 1.0 ～ 6. 6 μmoL/L for woman. Conclusions The level of TBIL and DBIL in physical examination population was higher than the existing reference interval. It is necessary to modify the existing reference interval and establish reasonable reference interval for different regions and gender, respectively.
出处
《中国医师杂志》
CAS
2013年第1期7-10,共4页
Journal of Chinese Physician
基金
国家自然科学基金资助项目（30971395）
关键词
胆红素
血液
体格检查
参考值
性别因素
Bilirubin/blood
Physical examination
Reference values
Sex factors
