摘要
目的探讨乳腺癌前哨淋巴结（sentinel lymphnode，SLN）解剖学定位及临床意义，为临床提供参考。方法回顾性分析2011年1月至2012年7月行乳腺癌前哨淋巴结活检患者152例，染料组术前15min将1％亚甲蓝2m1注射在肿瘤周围皮下组织的方法检测前哨淋巴结；观察组在染料法的基础上联合核素法，参照腋窝淋巴结结果，计算2组前哨淋巴结活检的诊断准确性、敏感度和假阴性率，分析前哨淋巴结的解剖学定位和前哨淋巴结活检的临床意义。结果观察组和染料组检出率、灵敏度、假阴性率及阳性预测率进行比较，其中检出率和假阴性率，差异有统计学意义（P〈0．05）；而两组的灵敏度及阳性预测率，差异无统计学意义（P〉0．05）。结论采用染料法联合核素法检测前哨淋巴结，是最可靠的定位方法，值得临床推广应用。
Objective To explore the anatomic location and clinical significance of sentinel lymph node in primary breast cancer. It provides reference for clinical. Methods 152 cases of breast cancer patients with sentinel lymph node biopsy were retrospective analyzed from January 2011 to July 2012. Preoperative dye group： 15 minutes by methylene blue injection in subcutaneous tissue around the tumor for detection of sentinel lymph nodes; the combination group used nuclear element method on the basis of the dye method, the accuracy, sensitivity and false negative rate were compared between the two groups with reference to the axillary lymph nodal, Results, 2 groups of sentinel lymph node biopsy in the diagnostic accuracy, sensitivity and false negative rate were calculated, and sentinel lymph nodes anatomical localization and clinical significance of sentinel lymph node biopsy were analyzed. Results For combination group and dye group, the detection rate, sensitivity, and false negative rate and positive predictive rate were compared, false negative rate and the detection rate, the difference were statistically significant （ P〈0.05 ） ; Sensitivity and positive predictive rate were compared, the difference was not statistically significant （ P〉0.05 ） . Conclusion Using dye method combined with radionuclide for the detection of sentinel lymph node is the most reliable method of positioning, it is worthy of clinical application.
出处
《浙江临床医学》
2013年第1期32-34,共3页
Zhejiang Clinical Medical Journal
关键词
乳腺癌
前哨淋巴结
假阴性率
解剖定位
Breast cancer The sentinel lymph node False negative rate Anatomic localization
