摘要
白念珠菌(Candida albicans)是临床上发生最为普遍的致病真菌,严重时可危及生命,目前主要以三唑类药物进行防治。但是由于药物长期广泛的使用及其作用位点的单一性,导致耐药问题日益突出。中药黄连解毒汤有良好的抑菌效果,并极大增强西药杀菌作用,但至今相关其分子机制的研究鲜有涉及。本文在阐述目前国内外现有高通量基因测序技术的基础上,重点探讨了高通量技术在黄连解毒汤抗白色念珠菌机制研究中的应用。
Candida albicans is the most common clinical pathogenic fungus and life-threatening in serious situations. Triazole is the main drug used in clinic to prevent and treat individuals infected with Candida albicans presently. However, due to long-term extensive usage and single site of action, drug re- sistance problems have become increasingly prominent. Antimicrobial activity of Huanglian-Jiedu Decoction has been confirmed, and Huanglian-Jiedu Decoction has effective role in enhancing sterilization action of western medicine, but the molecular mechanism in which is rarely kown. In this article we discuss the cur- rent situation of the high-throughput sequencing thechnologies in the world, and focuse on the application and exploration of high-throughput sequencing thechnologies in the mechanism study of Huanglian-Jiedu Decoction antagonize Candida albicans.
出处
《环球中医药》
CAS
2013年第1期55-59,共5页
Global Traditional Chinese Medicine
基金
国家自然科学基金(30471565)
关键词
白念珠菌
黄连解毒汤
高通量测序技术
应用探讨
Candida albicans
Huanglian-Jiedu Decoction
High-throughput sequencingthechnology
Application and discussion
