摘要
目的探讨神经元特异性烯醇化酶(NSE)、乳酸脱氢酶(LDH)和C反应蛋白(CRP)动态检测在新生儿缺氧缺血性脑病(HIE)中的临床意义。方法检测68例缺氧缺血性脑病新生儿(HIE组)出生第3天、第7天和第10天血清中NSE(电化学法)、LDH(酶法)和CRP(免疫比浊法)的含量变化。另选35例健康足月新生儿作为对照。结果 HIE组出生3天血清NSE、LDH的水平分别为(36.5±6.81)ng/L、(481.27±23.00)U/L,明显高于对照组的(9.61±2.42)ng/L、(98.33±18.69)U/L,差异有统计学意义(P<0.01),第7天时有所下降,与对照组比较差异有统计学意义(P<0.05);CRP含量在第7天明显高于对照组(P<0.01),第10天明显下降,与对照组比较差异无统计学意义(P>0.05)。结论 HIE患儿生后脑损伤越重,血NSE、LDH水平越高,而且随病情恢复进行性降低,CRP应答迟发,联合检测对早期准确了解脑损伤有重要意义。
Objective To investigate clinical significance of dynamic detection for neurons specific enolase enzymes（NSE）,lac tate dehydrogenase（LDH） and C-reactive protein（CRP） in neonates with hypoxic ischemic encephalopath（HIE）. Methods 68 cases of neonates with HIE were detected for NSE,LDH and CRP on the third,seventh and tenth day after horn. 35 healthy full term newborns were enrolled as controls. Results The serum NSE and LDH levels in HIE groups on the third day after born（36.5±6. 81 ng/L and 481.27 ± 23. U/L） were obviously higher than those in control group （9.61 ±2.42 ng/L and 98.33 ± 18. 69, P〈C 0. 01 ）. There were significance decline on the seventh day, but also higher than control group（P〈0.05）. CRP level on the seventh day was obviously higher than that in control group（26.8±7.2 mg/L, P〈0.01）. There was obvious decrease on the tenth day, and with no statistical difference with control group（P〉0.05）. Conclusion Blood level of NSE and LDH might increase with the in-creasing of the severity of brain injury in neonates with HIE, and could decrease with the recovery of disease. Combined detection of NES, LDH and CRP could be important for evaluating the severity of brain injury.
出处
《国际检验医学杂志》
CAS
2013年第4期402-403,406,共3页
International Journal of Laboratory Medicine
关键词
磷酸丙酮酸水合酶
L-乳酸脱氢酶
C反应蛋白
脑缺血
缺氧
脑
婴儿
新生
疾病
phosphopyrurate hydratase
L-lactate dehydrogenase
C-reactive protein
brain ischemia
hypoxia,braiminfant, newborn, diseases
