摘要
目的考察不同温度下,不同放置时间对丹参注射液与溶媒配伍后不溶性微粒变化的影响。方法采用显微镜法测定在不同温度下(4、25、36℃)丹参注射液与生理盐水注射液、5%葡萄糖注射液、10%葡萄糖注射液配伍后放置不同时间(0、60、120 min)的不溶性微粒数。结果整体上不溶性微粒数随温度的升高呈下降趋势;在4℃的环境下,丹参注射液与生理盐水、5%葡萄糖注射液及10%葡萄糖注射液配伍时,不溶性微粒随着放置时间延长呈增加趋势;在25℃的环境下,不溶性微粒数随时间变化不明显;在36℃的环境下,丹参注射液与生理盐水、5%葡萄糖注射液配伍时,不溶性微粒随着放置时间延长呈下降趋势,而10%葡萄糖注射液配伍时,则变化不明显。结论生理盐水注射液及5%葡萄糖注射液为丹参注射液较为适宜的配伍溶液,在低温及常温环境下,尽量现配现用,输液时可对液体适当加温。
Objective To study the effects of different temperatures and time on insoluble particles in DanShen injections when mixed with different solvents. Methods The numbers of insoluble particles in DanShen injections compatible with 0.9%NaC1, 5%GS and 10%GS at different temperatures （4℃, 25℃, 36℃） and different times （0 min, 60 min, 120 min） were measured by microscope respectively. Results On the whole, the number of insoluble particles decreased as the temperature increased. At the temperature of 4℃, the number of insoluble particles increased with the increase of time while at the temperature of 25℃, the number of insoluble particles showed no significant change. At the temperature of 36℃, when DanShen injections were mixed with 0.9%NaC1 and 5%GS, the number of insoluble particles declined with the increase of time and when mixed with 10%GS, there was no clear quantity change of insoluble particles. Conclusion DanShen injections mixed with 0.9%NaC1 and 5%GS are better choices than that mixed with 10% GS. The solution is better to be used right after it is ready and it can be warming properly during the infusion process.
出处
《护理学报》
2013年第3期69-71,共3页
Journal of Nursing（China）
基金
广东省2011年建设中医药强省资助科研课题(20111248)
广东省特色专业资助项目(粤教高函2010-96)
关键词
丹参注射液
不溶性微粒
温度
时间
DanShen injection
insoluble particle
temperature
time
