摘要
目的探讨呋塞米片含量测定的方法。方法在波长280 nm处,呋塞米以其在0.1 mol.L-1氢氧化钠溶液为参比液,测得其在0.1 mol.L-1盐酸溶液中的差示吸收值。结果呋塞米浓度在5.10～40.84 mg·L-1范围内ΔA与溶液浓度呈良好线性关系(r=0.999 9),平均回收率为99.69%(n=6),RSD为0.95%。结论该方法简便、快速、准确,可用于呋塞米片的质量控制。
Objective To find out a method to determine the Furosemide tablets.Methods The differential absorptions of furosemide in 0.1 mol·L-1 NaOH and in 0.1 mol·L-1 HCl were determined at the detection wavelength of 280 nm.Results The calibration curves showed good linearity in the range from 5.10 to 40.84 mg·L-1（r=0.999 9）.The average recovery rate（n=6）was 99.69%,and RSD was 0.95%.Conclusion The method is simple,quick and accurate,which can be a quality standard of furosemide tablets.
出处
《安徽医药》
CAS
2012年第8期1080-1081,共2页
Anhui Medical and Pharmaceutical Journal
关键词
差示分光光度法
呋塞米
测定
differential spectrophtometry
furosemide
determination
