摘要
目的通过总结分析中国儿童白血病协作组(CCLG)-08方案标危型(SR)的治疗效果,探讨进一步提高儿童急性淋巴细胞白血病(ALL)无事件生存率(EFS)的方法。方法分析2008年4月至2011年3月华中科技大学同济医学院附属协和医院儿科首诊并全程接受CCLG-08方案治疗的62例SR-ALL患儿临床资料。采用Kaplan-Meier方法评估患儿EFS,全部数据用SPSS软件分析。结果 62例患儿诱导治疗完全缓解率(CR)96.8%;失访4例(6.5%);1、2、3年总EFS率分别为(95.2±2.7)%、(93.5±3.1)%、(93.5±3.1)%。复发2例(3.2%),均为CNSL,无睾丸白血病复发和第二肿瘤发生。死亡3例,病死率(4.8%),其中化疗相关死亡2例(3.2%)。结论 CCLG-08方案治疗儿童SR-ALL的EFS接近发达国家水平。规范分型诊断及阶段疗效评估有利于患儿个体化治疗,降低复发率,减少副反应,提高生存质量。
Objective To analyse the treatment outcome of pediatric standard-risk acute lymphoblastic leukemia （SR-ALL） with CCLG-08 protocol, and to provide theoretical evidences for further improving the event-free survival （EFS）.Methods A prospective study was carried out on the children with newly diagnosed SR-ALL in our department. Kaplan-Meier methods was used to estimate EFS.Data were analyzed by SPSS. Results A total of 62 patients were recruited and treated with the CCLG-08 protocol.The complete remission rate of induction （CR） was 96.8%, 4 patients （6.5%） dropped out of the protocol.The overall EFS was （95.2 ± 2.7）%, （93.5 ± 3.1 ）% and （93.5 ±3.1 ）% in 1 year, 2 years and 3 years, respectively.Relapse occurred in 2 patients （3.2.fro）, all of whom were isolated central nervous system （CNS）, no testicular leukemia relapse and second tumor occurred.Three patients died and the mortality rate was 4.8%, with 2 deaths due to chemotherapy complications. Conclusion The tolerance of the CCLG-ALL-08 protocol was favorable, and the EFS rate is close to that of the best level in the world.The standardized clinical risk classification and periodical assessment of treatment effect contribute to lowering relapse rate, reduceing complication, and improving the quality of life.
出处
《中国实用儿科杂志》
CSCD
北大核心
2013年第2期111-113,共3页
Chinese Journal of Practical Pediatrics
基金
国家"十一五"科技支撑计划课题项目(编号:2007BAI04B03)
关键词
急性淋巴细胞白血病
儿童
无事件生存
acute lymphoblastic leukemia
childhood
event-free survival
