摘要
利用pTLC、硅胶、Sephadex LH-20及半制备HPLC等柱色谱手段,从海洋真菌Penicillium oxalicum SCS-GAF 0023的次生代谢产物中分离得到16个化合物,波谱学数据分析鉴定为n-butyl isobutyl terephthalate(1),dibutyl terephthalate(2),1,3,7-trihydroxy-6-methylanthraquinone(3),1,6,7-trihydroxy-3-methoxy-anthraquinone(4),isorhodoptilometrin(5),citreorosein(6),emodin(7),methyl-3,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate(8),pinselin(9),secalonic acid D(10),quinolactacin C1(11),quinolactacin C2(12),quinolactacin A1(13),quinolactacin A2(14),quinolactacin B1(15),3-methyl-1H-indole-2-carboxylic acid(16)。其中,化合物1为新天然产物,化合物5和7表现出强的抗草苔虫幼虫附着活性,EC50值分别为3.8和6.0μg/mL;化合物10和15分别对PTPIB和cathepsin B显示中等的酶抑制活性,IC50值分别为24.0和16.0μM。
Sixteen compounds were isolated from marine-derived fungus Penicillium oxalicum SCSGAF 0023 strain. They were identified to be n-butyl isobutyl terephthalate （ 1 ）, dibutyl terephthalate （2）, 1,3,7-trihydroxy-6-methylanthra- quinone （3）, 1,6,7-trihydroxy-3-methoxy-anthraquinone （ 4 ）, isorhodoptilometrin （ 5 ）, citreorosein （ 6 ）, emodin （7）, methyl-3,8-dihydroxy-6-methyl-9- oxo-9H-xanthene-1 -carboxylate （ 8 ）, pinselin （ 9 ）, secalonic acid D （ 10 ）, quinolactaein C1 （ 11 ）, quinolactacin C2 （ 12）, quinolaetacin A, （ 13）, quinolactacin A2 （ 14）, quinolactaein B, （ 15 ）, and 3-methyl-1H-indole-2-carboxylie acid （16） on the basis of spectroscopic analysis and comparison with literatures. Compound I was a new natural product. Compounds 5 and 7 showed strong antifouling activity with ECso values of 3.8 and 6.0 μg/ml, respectively. Compound 10 exhibited moderate inhibitory activity against PTPIB with IC50 value of 24.0 μM, and 15 showed moderate inhibitory activity against cathepsin B with IC50 value of 16.0 μM.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2013年第1期1-6,59,共7页
Natural Product Research and Development
基金
国家973前沿领域项目(2010CB833800)
国家自然科学基金项目(40931160435,40976090)
