期刊文献+

抗丙型肝炎病毒新药Boceprevir 被引量:1

原文传递
导出
摘要 目前全球约有1.8亿[1]丙型肝炎病毒(HCV)感染者,由于患者在感染HCV后,转化为慢性肝炎的比例很高,甚至发展为肝硬化和肝癌,因此,丙肝成为了人们健康的巨大威胁。丙肝治疗的标准方案(standard of care,SOC)是聚乙二醇干扰素联合利巴韦林。
作者 许寅
出处 《中国药学杂志》 CAS CSCD 北大核心 2013年第4期317-318,共2页 Chinese Pharmaceutical Journal
  • 相关文献

参考文献10

  • 1Sarrazin C,Rouzier R,Wagner F,et al.SCH 503034,a novel hepatitisC virus protease inhibitor,plus pegylated interferom alpha-2b forgenotype 1 nonresponders[].Gastroenterology.2007
  • 2FDA.JAKAFI (Ruxolitinib)label[]..2011
  • 3Kwo PY,Lawitz EJ,McCone J,et al.Efficacy of boceprevir,an NS3 protease inhibitor,in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1) an open-label,randomised,multicentre phase 2 trial[].The Lancet.2010
  • 4Bennett F,Huang YH,Hendrata S, et al.The introduction of P4 substituted 1-methylcyclohexyl groups into boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor[].Bioorganic and Medicinal Chemistry.2010
  • 5K. Lin,A. D. Kwong,C. Lin.Combination of a hepatitis C virus NS3-NS4A protease inhibitor and alpha interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells[].Antimicrobial Agents and Chemotherapy.2004
  • 6http://www.fda.gov/downloads/AdvisoryCommittees/Commit-teesMeetingMaterials/Drugs/AntiviralDrugsAdvisoryCommittee/UCM254076.pdf .
  • 7LATHA G N,MOUSUMI S,STEPHANE B,et al.P4 capped amidesand lactams as HCV NS3 protease inhibitors with improved potencyand DMPK profile[].Bioorganic and Medicinal Chemistry.2010
  • 8WWW.fda.gov/ForConsumers/ByAudience/ForPatientAdvo-cates/ucm255413.htm . 2011
  • 9http://www.fda.gov/downloads/AdvisoryCommittees/Commit-teesMeetingMaterials/Drugs/AntiviralDrugsAdvisoryCommittee/UCM252343.pdf .
  • 10http://www.fda.gov/downloads/AdvisoryCommittees/Commit-teesMeetingMaterials/Drugs/AntiviralDrugsAdvisoryCommittee/UCM252341.pdf .

同被引文献7

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部