摘要
目的探讨转移因子治疗小儿反复呼吸道感染疗效及安全性,为临床诊治提供参考依据。方法选取医院儿科2009年5月-2012年2月收治小儿反复呼吸道感染患儿180例,入选患儿采用随机数字表法分为丙种球蛋白组90例,转移因子组90例,疗程均为4周;比较两组患儿临床治疗总有效率,退热、住院时间,治疗前后血清IgG、IgA水平及不良反应发生等。结果丙种球蛋白组和转移因子组患者临床治疗总有效率分别为62.2%、91.1%;丙种球蛋白组患儿退热及住院时间分别为(4.54±1.57)、(7.64±2.63)d;转移因子组患儿退热及住院时间分别为(3.25±1.15)、(4.80±1.97)d;转移因子组患儿临床治疗总有效率、退热及住院时间明显优于丙种球蛋白治疗组;治疗后两组患儿血清IgG、IgA水平较治疗前均有显著改善,且转移因子组患儿改善程度明显优于丙种球蛋白组,组间比较差异均有统计学意义(P<0.05);丙种球蛋白组与转移因子组患儿治疗过程中分别出现注射部位肿痛3例、4例,停止注射后均自行缓解;无严重肝肾功能损害病例出现。结论转移因子治疗小儿反复呼吸道感染近期疗效满意,能够有效改善临床症状,缩短治疗时间,提高血清抗体水平,且不良反应较少。
OBJECTIVE To explore the effectiveness and safety of transfer factor in the treatment of infantile repeated respiratory infections so as guide the clinical diagnosis and treatment.METHODS A total of 180 children with recurrent respiratory tract infections who were admitted to the pediatrics department of the hospital from May 2009 to Feb 2012 were enrolled in the study and were randomly divided into two groups,with 90 cases treated with immunoglobulin,and 90 cases treated with transfer factor,the treatment course was 4 weeks.The total clinical effective rate,fever,duration of hospitalization,serum IgG,IgA levels before and after the treatment,and the adverse reactions were compared between the two groups.RESULTS The total effective rates of the immunoglobulin group and the transfer factor group were 62.2% and 91.1%,respectively.The fever time of the immunoglobulin group and the transfer factor group were（4.54 ±1.57） d and（3.25±1.15）d,respectively,and the hospitalization duration of the two groups were（7.64 ±2.63） d and（4.80 ±1.97） d,respectively;the transfer factor was significantly superior to the immunoglobulin in the total effective rate,fever and hospitalization duration;after the treatment,the serum IgG,IgA levels of the two groups of children were significantly improved as compared with those before the treatment,and the transfer factor group improved more significantly than did the immunoglobulin group,the difference between the groups was statistically significant（P0.05）.There were 3 cases with injection site pain in the immunoglobulin therapy group and 4 cases in the transfer factor group during the treatment course,and the pain was relieved as the injection stopped;there were no cases with severe liver and kidney function damage.CONCLUSION The transfer factor can achieve satisfying effect on the treatment of infantile repeated respiratory infections,can effectively improve the clinical symptoms and shorten the treatment time,and can increase the serum antibody level,with producing less adverse reactions.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第4期862-863,共2页
Chinese Journal of Nosocomiology
关键词
转移因子
小儿
呼吸道感染
疗效
安全性
Transfer factor
Pediatric
Respiratory tract infection
Curative effect
Safety
