摘要
目的分析服用双磷酸盐药物对骨质疏松的患者行口腔外科手术后发生的感染,控制围手术期相关药物的使用。方法采用回顾性研究方法对行手术治疗的骨质疏松患者临床资料进行分析,以术前5周是否有使用双磷酸盐类药物分为观察组和对照组,对两组患者基础指标及术后发生感染进行统计分析,并对药物使用时间及感染进行相关分析。结果共纳入患者213例,其中观察组148例,对照组65例,两组患者性别差异无统计学意义,观察组患者吸烟、饮酒、糖尿病分别为21.6%、27.7%、2.0%,对照组患者分别为26.2%、36.9%、3.1%,两组比较,差异无统计学意义;观察组术后27例发生感染,感染率18.24%,对照组4例发生感染,感染率6.15%,两组比较差异有统计学意义(P<0.05);进一步分析发现随着药物使用时间的增长,其感染率逐渐增大。结论双磷酸盐可增加口腔外科术后感染概率,对合并骨质疏松患者术前5周应酌情考虑停用或减量双磷酸盐类药物。
OBJECTIVE To evaluate the effect of bisphosphonates on the postoperative infections in the osteoporosis patients who underwent oral surgery so as to control the perioperative use of relevant drugs.METHODS The clinical data of the osteoporosis patients who underwent surgery were retrospectively analyzed,the patients were divided into the observation group and the control group according to the use of bisphosphonate during 5 weeks before the surgery,and the statistical analysis was performed on the basic characteristics and infection rates.Additionally,the correlation between the time of using antibiotics and the infections was analyzed.RESULTS A total of 213 cases were included,148 cases in the observation group,65 cases in the control group.The difference in the gender between the two groups was not statistically significant.In the observation group,the patients with smoking history accounted for 21.6%,the patients with drinking 27.7%,and the patients with diabetes mellitus 2.0%,and in the control group they were 26.2%,36.9%,and 3.1%,respectively,the difference between the two groups was not statistically significant.There were 27（18.24%） infected cases that were detected after the surgery in the observation group,while there were 4（6.15%） infected cases detected after the surgery in the control group,the difference was statistically significant（P0.05）.Further analysis confirmed that there was a positive correlation between drug use time and the infection rate.CONCLUSION Bisphosphonates can increase the risk of infections after oral surgery.The osteoporosis patients should stop using or reduce the dosage of bisphosphonates during five weeks before the surgery.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第4期833-835,共3页
Chinese Journal of Nosocomiology
关键词
双磷酸盐
骨质疏松
口腔颌面外科
感染
Bisphosphonates
Osteoporosis
Oral and maxillofacial surgery
Infection
