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Arsenic trioxide in treatment of de novo acute basophilic leukemia 被引量:1

Arsenic trioxide in treatment of de novo acute basophilic leukemia
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摘要 Acute basophilic leukemia (ABL) is a rare subtype of .acute myeloid leukemia (AML), accounting for 4%-5% of AML and less than 2% of all hematopoietic malignancies. It is usually characterized by a very rapid clinical course, symptoms of hyperhistaminemia, peptic ulceration, gastrointestinal cerebrovascular bleeding and resistance to therapy.^1 However, the clinical outcome of ABL remains disapp2ointing. Most patients died within 1 year after diagnosis. Acute basophilic leukemia (ABL) is a rare subtype of .acute myeloid leukemia (AML), accounting for 4%-5% of AML and less than 2% of all hematopoietic malignancies. It is usually characterized by a very rapid clinical course, symptoms of hyperhistaminemia, peptic ulceration, gastrointestinal cerebrovascular bleeding and resistance to therapy.^1 However, the clinical outcome of ABL remains disapp2ointing. Most patients died within 1 year after diagnosis.
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第3期593-594,共2页 中华医学杂志(英文版)
关键词 acute basophilic leukemia arsenic trioxide acute basophilic leukemia arsenic trioxide
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参考文献5

  • 1Krawczynska A,Robak T. Acute basophilic leukemia[J].Acta Haematologica Polonica,1994.323-327.
  • 2Giagounidis AA,Hildebrandt B,Heinsch M,Germing U Aivado M Aul C. Acute basophilic leukemia[J].European Journal of Haematology,2001.72-76.
  • 3Duchayne E,Demur C,Rubie H,Robert A Dastugue N. Diagnosis of acute basophilic leukemia[J].Leukemia and Lymphoma,1999.269-278.
  • 4Sugimoto N,Ishikawa T,Gotoh S,Shinzato I Matsushita A Nagai K. Primary myelofibrosis terminated in basophilic leukemia and successful allogeneic bone marrow transplantation[J].International Journal of Hematology,2004.183-185.
  • 5Chen S J,Zhou GB,Zhang XW,Mao JH de Thé H Chen Z. From an old remedy to a magic bullet:molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia[J].Blood,2011.6425-6437.

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