摘要
目的通过马来酸桂哌齐特注射液与低分子右旋糖酐的不良反应比较，为断指再植术后患者选择一种有效、安全、不良反应较少的抗凝药。方法从2010年4月至2012年4月期间在我院行单指断指再植术患者，观察组120例术后予马来酸桂哌齐特注射液320mg／d静滴，对照组120例予低分子右旋糖酐500ml／d静滴，余治疗无差异。观察记录药物不良反应。结果观察组和对照组治疗有效率分别为96．67％和92．50％，两组问差异无统计学意义（P〉0．05），但观察组不良反应发生率仅为5．80％，显著低于对照组的14．17％，差异有统计学意义（P〈0．05）。结论马来酸桂哌齐特注射液和低分子右旋糖酐用于断指再植术后都有较好的临床疗效，均能明显改善微循环，提高再植成活率。但马来酸桂哌齐特注射液具有不良反应少的特点，是目前断指再植术后较理想的抗凝药物，值得临床应用。
Objective Comparing the clinical effect between Cinepazide Maleate and low Molecular weight Dextran, to the one which is more effective, safer and less unheahhy to patients after digital replantation. Methods From April 2010 to April 2012 in our hospital during single finger replantation patients, the obser- vation group 120 cases of postoperative to Cinepazide Maleate injection 320mg/d intravenous drip, the control group of 120 cases treated with low Molecular Dextran 500ml/d IVGTT. Results The effective rate of observe group and control group was 96. 67% and 92.50% , respectively. The difference between the two groups was too small to have statistically significant difference （ P 〉 0. 05 ） , but the adverse effect of treatment group was only 5.8% , much lower than 14. 17% in control group however with the statistically significant difference （P 〈 0. 05 ）. Conclusion Cinepazide Maleate injection and low Molecular weight Dextran both have apparent effect in patients after digital replantation surgery. Both of them significantly improved mierocirculation, en- hanced the survival rate of replantation. However Cinepazide Maleate injection has fewer adverse effects, which is one of idea auxiliary medicine and deserved more extensive clinic application in currently microsurgery.
出处
《中华显微外科杂志》
CSCD
北大核心
2013年第1期36-39,共4页
Chinese Journal of Microsurgery
关键词
马来酸桂哌齐特注射液
低分子右旋糖酐
断指再植
不良反应
Cinepazide Maleate injection
Low molecular weight dextran
Digital replantation
Adverse effect
