摘要
目的探讨年龄和血基础促卵泡素(FSH)水平对不孕妇女夫精人工授精结局的影响。方法回顾性分析我院生殖健康科2006年1月～2011年12月接受夫精人工授精治疗的不孕患者的年龄和基础FSH水平与临床妊娠率和流产率的关系。结果共计257例,535周期。年龄<35岁组临床周期妊娠率为15.1%,≥35岁组为13.2%(P>0.05);年龄<35岁组流产率为19.0%,低于≥35岁组的50%(P<0.05)。在<35岁组,促排卵周期妊娠率(25.0%)高于自然周期(11.1%)(P<0.05),但在≥35岁组,其差异无统计学意义。基础FSH<10IU/L组与≥10IU/L组妊娠率无显著性差异,但流产率降低(22.4%vs.54.5%,P<0.05)。FSH<10IU/L组促排卵周期妊娠率为23.1%,高于自然周期组的12.3%(P<0.05),而FSH≥10IU/L组促排卵周期妊娠率与自然周期妊娠率无显著性差异。结论高龄和基础FSH升高的不孕妇女夫精人工授精妊娠率下降,而流产率上升,促排卵不能增加高龄和高FSH患者的人工授精妊娠率。
Objective： To explore the impacts of age and basal follicle-stimulating hormone（FSH） levels on outcomes of infertile women undergoing artifical insemination by husband′s sperm（AIH）.Methods： The correlations between age or basal FSH levels and clinical pregnancy rates（PR） and miscarriage rates（MR） were analyzed retrospectively in infertile women undergoing AIH in our department between 2006 and 2011.Results： Total of 535 cycles.There was no significant difference in PR between35 age-group and ≥35 age-group（15.1% vs.13.2%,P0.05）,but the MR was significantly lower in35 age-group than in ≥35 age-group（19.0%vs.50.0%,P0.05）.Moreover,the PR was significantly higher in ovarian stimulating cycles（25.0%） than natural cycles in35 age-group（11.1%）（P0.05）.The elevated FSH group was found with a significant higher MR than the normal FSH group（54.5% vs.22.4%,P0.05）,in which the PR was significantly higher in ovarian stimulating cycles（23.1%） than in natural cycles（12.3%）（P0.05）.Conclusion： A elevated FSH or age in infertile women undergoing AIH therapy will result in a low PR and high MR,which cannot be improved by ovarian stimulation.
出处
《中国优生与遗传杂志》
2013年第1期95-96,90,共3页
Chinese Journal of Birth Health & Heredity
关键词
夫精人工授精
年龄
促卵泡素
临床妊娠率
Artificial insemination with husband＇s sperm （AIH）
Age
Follicle -stimulating hormone （FSH）
Pregnancy rate
