摘要
目的:探讨在糖尿病患者中采用胰周动脉超选择插管法用于灌注自体骨髓干细胞的安全性、可行性.方法:对24例糖尿病患者,首先行腹腔干、肝动脉、脾动脉造影,仔细观察、评价胰周动脉情况.然后以同轴微导管对目标胰周动脉进一步行超选择插管.成功后,经导管缓慢注入含自体骨髓干细胞的分离液.对于胰周动脉扭曲、细小,插管困难者,采用球囊辅助下灌注自体骨髓干细胞的分离液的方法.观察超选择插管成功率、花费时间及相关并发症.结果:全部24例患者中,23例成功完成胰周动脉超选择插管,成功率95.8%.其中,胰背动脉超选择插管7例,胰大动脉8例,胰尾动脉4例,胰头周围血管4例.1例失败患者,改行球囊辅助下灌注干细胞治疗.全部患者未出现血管痉挛、穿孔、动脉夹层、血管闭塞、血栓形成等并发症.插管花费时间25-190min,中位时间55min.结论:本研究初步提示胰周动脉超选择插管是1种注入自体骨髓干细胞安全、可行的方法.
AIM： To evaluate the safety and feasibility of superselective peripancreatic arterial catheterization for infusion of autologous bone marrow stem cells in diabetic patients. METHODS： A total of 24 patients with diabetes mellitus underwent celiac trunk, hepatic artery and splenic artery angiography, and peripancreatic arteries, which origin from these arteries, were carefully evaluated. One of these peripancreatic arteries was superselectively catheterized with a coaxial microcatheter. After the microcatheter reached the peripancreatic artery, autologous bone marrow stem cells were slowly injected into the artery transcatheterly. For distorted or small peripancreatic arteries that made catheterization difficult, balloon-assisted infusion of autologous bone marrow stem cells was utilized. Success rate, time required for the procedure and complications were evaluated. RESULTS： Superselective peripancreatic arterial catheterization was successful in 23 of 24 patients, with a success rate of 95.8%. Superselective catheterization of the dorsal pancreatic artery was performed in 7 cases, the great pancreatic artery in 8 cases, the caudal pancreatic artery in 4 cases and the pancreatic artery supplying pancreatic head in 4 cases. The patient with the failed procedure was converted to balloon-assisted infusion of stem cells. Complications such as spasm, perforation, dissection, vascular occlusion and thrombosis were not observed. The time required for the procedure ranged from 25 to 190 min, with a median value of 55 min. CONCLUSION： Superselective peripancreatic arterial catheterization is a safe and feasible method for infusion of autologous bone marrow stem cells in diabetic patients.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第3期272-277,共6页
World Chinese Journal of Digestology
关键词
胰周动脉
超选择插管
糖尿病
自体骨髓干细胞
移植
Peripancreatic arterial
Superselective catheterization
Diabetes mellitus
Autologous bone marrow stem cells
Transplant
