摘要
上皮-间质转化(epithelial-mesenchymal transition,EMT)是上皮细胞通过特定的程序转化为间质细胞的生物学过程,EMT在胚胎发育、创伤愈合、肿瘤的侵袭迁移等过程中起重要作用,EMT在恶性肿瘤的侵袭迁移病理过程中的分子机制成为研究热点,尤其是消化系肿瘤方面.由于上皮性肿瘤在恶性肿瘤中所占比例较大及转归预后较差,探究上皮细胞在获得迁移侵袭能力的过程,即EMT过程,为消化系肿瘤的预防和治疗提供方向.EMT的研究将为消化系肿瘤患者的预后和抗肿瘤药物的应用提供依据.本文对EMT的机制和在消化系肿瘤方面的研究进展作一综述.
Epithelial-mesenchymal transition （EMT） refers to the process by which cells transit from epithelial phenotype to mesenchymal phenotype. EMT is important for embryonic development, wound healing, and invasion of carcinomas. The molecular mechanisms of EMT are a hot topic of research in invasion and migration of malignant tumors, especially digestive carcinomas. Since malignant epithelial tumors account for a large proportion of tumors and are associated with very poor outcome and prognosis, exploration of the process of epithelial cell migration and invasion is of great significance for the prevention and treatment of tumors. The investigation of EMT provides a basis for understanding the pathogenesis of tumors and their prognosis and resistance to antitumor drugs. This review focuses on the molecular mechanisms and role of EMT in gastrointestinal tract tumors.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第3期205-210,共6页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81172356
天津市重点基础科技项目基金资助项目
No.10JCZDJC18500~~
关键词
上皮-间质转化
消化系肿瘤
Epithelial-mesenchymal transition
Gastrointestinal tract tumors
