摘要
DNA和RNA具有精确的分子识别能力以及强大的信号存储能力.利用DNA/RNA分子的生物学特性来构建分子级别的逻辑门并实现逻辑运算是近年来计算机科学和分子生物学交叉产生的新兴领域,引起了研究者的广泛关注.本文介绍了利用DNA/RNA分子的酶活性、结构特性来构建逻辑门的方法,探讨了将单一逻辑门整合成复杂的逻辑运算的途径.并且对于DNA/RNA逻辑门在体外检测和体内诊疗等生物医学中的应用进行了介绍,提出了未来的发展方向.
DNA and RNA molecules possess precise recognition and powerful signal storage abilities.By exploiting their biological properties,it is possible to construct molecule-scale logic gates and realize logistic operations which,as an emerging multidisciplinary area between computer sciences and molecular biology,has intrigued great research attention.In this article,we summarize methods to construct logic gates by exploiting enzymatic and structural properties of DNA and RNA,and approaches to integrate logic gates into complex logistic operations.Finally,we introduce biomedical applications of DNA/RNA logic gates for in-vitro detection and in-vivo diagnosis and therapy.
出处
《科学通报》
EI
CAS
CSCD
北大核心
2013年第2期131-140,共10页
Chinese Science Bulletin
关键词
逻辑门
DNA计算
分子识别
自组装
生物计算机
logic gate
DNA computing
molecular recognition
self-assemble
bio-molecular computer
