摘要
目的探讨颅内动脉瘤破裂后,患者血清促肾上腺皮质激素、甲状腺激素水平的变化情况。方法监测2010年3月-6月共51例动脉瘤患者术前、术后2～3、4～5 d促肾上腺皮质激素(ACTH)、甲状腺激素水平的变化情况,并对监测结果进行统计学处理。结果 ACTH、促甲状腺激素、甲状腺素、血清游离甲状腺素在术前、术后2～3、4～5 d差异无统计学意义(P>0.05),三碘甲状腺原氨酸(T3)、血清游离三碘甲状腺原氨酸(FT3)在术前、术后2～3、4～5 d差异有统计学意义(P<0.05);不同部位动脉瘤患者的T3、FT3在术前、术后2～3、4～5 d差异无统计学意义(P>0.05);Fisher、Hunt分级不同级别的动脉瘤患者的T3、FT3在术前、术后2～3、4～5 d差异有统计学意义(P<0.05)。结论动脉瘤破裂患者的血清T3、FT3的变化水平情况,可以作为判断患者病情的轻重与预后的一项重要指标。
Objective To investigate the changes of serum adrenocorticotropic hormone（ACTH） and thyroid hormone level after the rupture of intracranial aneurysm.Methods We monitored the ACTH and thyroid hormone level in 51 patients with intracranial aneurysm between March to June 2010 before surgery,two to three days after and four to five days after surgery.The results of the monitoring were statistically analyzed.Results ACTH,thyrotropin,thyroxine,and free thyroxine were not significantly different among the three time periods（P0.05）,while triiodothyronine（T3） and free triiodothyronine（FT3） were significantly different（P0.05）.T3 and FT3 were not significantly different among patients with aneurysm of different locations（P0.05）.However,they were significantly different among patients with different Fisher and Hunt-Hess levels.Conclusions The changes of serum T3 and FT3 levels can be an important index to estimate the disease severity and prognosis.
出处
《华西医学》
CAS
2013年第1期40-43,共4页
West China Medical Journal
