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异柠檬酸脱氢酶-2基因小干扰RNA对人肝癌细胞SMMC-7721的抑瘤作用 被引量：1

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摘要 能量代谢在肿瘤发生发展中起重要的作用，其中三羧酸循环的异柠檬酸脱氢酶（IDH）在许多肿瘤中发生突变，可能是因为这些突变通过激活原癌基因或抑制抑癌基因的途径导致肿瘤发生。目前国内外对IDH一2基因研究主要集中于神经胶质瘤和急性髓性白血病[1]，在肝癌中报道尚少。
作者 金一琦 沈利明 周大勇 陈磊 黄献琛
机构地区 南京医科大学附属苏州医院苏州市立医院本部介入血管科
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2013年第2期408-408,共1页 Chinese Journal of Experimental Surgery
基金 南京医科大学青年自然科学基金资助项目（09NJMUMl40）
关键词 人肝癌细胞SMMC-7721 异柠檬酸脱氢酶 抑癌基因 小干扰RNA 抑瘤作用 肿瘤发生发展 急性髓性白血病 三羧酸循环
分类号 R735 [医药卫生—肿瘤]
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同被引文献14

  • 1李臣宾 ,张峰 ,史玉荣 ,魏熙胤 ,杨毅 ,牛瑞芳 .小干扰RNA引发多药耐药乳腺癌细胞内MDR1基因沉默的研究[J].中华实验外科杂志,2004,21(10):1199-1201. 被引量：18
  • 2罗顺峰,陈孝平,朱虹,关剑,张必翔.肝癌多药耐药产生与低糖环境的关系[J].中华实验外科杂志,2007,24(2):182-184. 被引量：11
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中华实验外科杂志
2013年 第2期

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