摘要
目的探讨盐酸戊乙奎醚(长托宁)治疗脓毒性休克的临床应用价值。方法将我院2010年2月至2011年12月收治的80例脓毒性休克患者随机分为A(对照组)、B、C、D 4组,每组20例。A组采用常规治疗手段,B、C、D组在常规治疗的基础上,静脉注射不同浓度的长托宁,观察各组的临床疗效。结果 80例患者成功抢救69例,死亡11例,抢救成功率为86.25%。其中A、B、D组抢救成功17例,病死3例。C组抢救成功18例,病死2例。四组的治愈率分别为85%、85%、90%和85%,差异无统计学意义(P>0.05)。静脉注射低剂量(2mg)长托宁后,患者的心率、MAP、肠鸣音等与对照组比较差异有统计学意义(P<0.05)。B组SpO2、血乳酸、末梢转暖时间、末梢转暖持续时间与A组比较差异有统计学意义,C、D组末梢转暖时间、末梢转暖持续时间与A组比较差异有统计学意义(P<0.05)。结论盐酸戊乙奎醚抢救脓毒性休克疗效显著,值得临床推广。
Objective To discuss the clinical value of hydrochloric acid penehyclidine （penehyclidine）treat-ment for septic shock. Methods 80 patients admitted to our hospital from February 2010 to December 2011 were ran-domly divided into 4 groups,20 cases in each group. Group A （control group）was given conventional treatment, on the basis of conventional treatment, B, C, D groups were given intravenous injection of different concentrations of penehy-clidine. The clinical efficacy of the 4 groups were observed. Results 69 cases were successfully rescued, 11 died, and the overall curative rate was 86. 25%. 17 cases of group A,group B ,group D were successfully rescued,3 died respec-tively. 18 cases of group C were were rescued,2 died. The curative rates of the four groups was 85% ,85% ,90% and 85% respectively（ P 〉 0.05 ）. After intravenous low-dose （ 2 mg ） penehyclidine, the patients＇ heart rate, MAP, bowel sounds were improved more significantly compared with control group （ P 〈 0. 05 ）. The patients＇ SpO2 , blood lactate, peripheral wanning time and peripheral warming lasting time of group B were improved more significantly compared with control group, and peripheral warming time, peripheral warming lasting time of group C and group D were obvi-ously improved more obviously than those of control group（ P 〈 0. 05 ）. Conclusion Hydrochloric acid penehyclidine rescuing septic shock has good efficacy, and it is worthy of clinical promotion.
出处
《实用药物与临床》
CAS
2013年第1期28-30,共3页
Practical Pharmacy and Clinical Remedies
关键词
长托宁
脓毒性休克
Penehyclidine
Septic shock
