摘要
目的探讨联合检测氨基末端B型钠尿肽原(NT-proBNP)和心肌肌钙蛋白I(cTnI)水平在急诊心力衰竭(HF)患者诊治中的应用。方法采用酶联免疫荧光法检测急诊室送检的708例心血管疾病患者(HF 195例、非HF 513例)血浆NT-proBNP和cTnI水平。将HF患者按美国心脏病协会纽约心脏学会(NYHA)心功能分级标准分为Ⅰ～Ⅳ级。检测结果采用中位数(四分位数)表示,采用秩和检验进行统计分析。结果 HF组血浆NT-proBNP和cTnI分别为3 718(1 035～12 258)ng/L、7.18(2.05～14.16)μg/L,明显高于非HF组[NT-proBNP为145(30～585)ng/L、cTnI为0.66(0.06～1.99)μg/L,P<0.01]。NYHAⅡ、Ⅲ、Ⅳ级HF患者之间NT-proBNP、cTnI水平差异有统计学意义(P<0.05)。联合检测NT-proBNP和cTnI的敏感性和特异性分别为99%和90%,远高于单项检测(P<0.05)。结论对于急诊室送检的疑似HF的心血管疾病患者血标本,及时进行NT-proBNP和cTnI水平的联合检测在HF的诊治中十分有价值。
Objective To investigate the application of combined detection of the N-terminal pro-B-type natriuretic peptide （NT-proBNP） and cardiac troponin I （cTnI） in the diagnosis and treatment of acute heart failure （HF） patients in emergency department. Methods Enzyme-linked immunosorbent fluorescence assay was used to determine plasma NT-proBNP and cTnI levels in 708 patients with cardiovascular diseases （ 195 patients with HF and 513 patients with non-HF）. According to the New York Heart Association （NYHA） cardiac function grades, the HF patients were classified into Grade I -IV. The results were expressed by medians （quartiles）. The results were analyzed statistically. Results The levels of NT-proBNP and cTnl in HF group were 3 718 （ 1 035-12 258） ng/L and 7.18 （2.05- 14.16） μg/L, respectively, which were significantly higher than those in non-HF group [145 （30-585） ng/L for NT- proBNP and 0. 66 （0.06-1.99） μg/L for cTnl, P 〈 0. 01 ]. Statistical significance was also observed when comparing NT-proBNP and cTnI levels of the patients with HF at NYHA Grade II , III and IV （P 〈 0. 05）. Furthermore, the sensitivity （99%） and specificity （90%） for the diagnosis of HF with the combined detection of NT-proBNP and cTnl were much higher than those with either the detection of NT-proBNP or cTnl alone （ P 〈 0. 05 ）. Conclusions The combined detection of NT-proBNP and cTnI has valuable significance in the diagnosis and treatment of HF in emergency department.
出处
《检验医学》
CAS
2013年第1期30-32,共3页
Laboratory Medicine
