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阿托伐他汀预防冠心病患者介入诊疗术后对比剂肾病的疗效观察 被引量：4

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摘要 目的探讨在常规治疗的基础上加用阿托伐他汀(立普妥)能否更有效地减少冠心病患者经皮冠状动脉介入性诊断和治疗术后对比剂肾病(Contrast-Induced Nephropathy,CIN)的发生率。方法将拟行冠脉介入诊断和治疗的患者262例,随机分为立普妥组(n=132例)和对照组(n=130例)。对照组常规给予抗血小板、抗凝、控制血压、血糖及水化等治疗。未服用立普妥及其他调脂药。立普妥组在常规治疗的基础上在使用对比剂前1～2d加用立普妥20mg QN至术后2月。比较两组患者CIN的发生率。结果两组患者共发生造影剂肾病15例(5.7%),其中对照组12例(9.2%),立普妥组3例(2.3%),两组对比剂肾病的发生率具有显著性差异(P<0.05)。结论对于对比剂剂引发的急性肾损伤,在常规水化治疗的基础上加用立普妥可以更有效地预防对比剂肾病的发生。
作者 王福贵 徐梅 李文华 王冬松 徐通达
机构地区 徐州医学院附属医院
出处 《中国实用医药》 2013年第2期144-145,共2页 China Practical Medicine
关键词 阿托伐他汀 对比剂肾病 预防
分类号 R541.4 [医药卫生—心血管疾病] R692.9 [医药卫生—泌尿科学]
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参考文献5

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共引文献728

同被引文献77

  • 1张庆娟（综述）,刘殿阁（审校）.造影剂肾病的防治进展[J].国际泌尿系统杂志,2007,27(1):117-120. 被引量：15
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引证文献4

二级引证文献11

中国实用医药
2013年 第2期

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