摘要
目的:观察2型糖尿病一级亲属的血糖漂移及干预的临床疗效。方法:门诊和病房随机抽取2型糖尿病一级亲属进行动态血糖监测。将发生血糖漂移的2型糖尿病一级亲属随机分为三组,生活方式干预组(21例)、阿卡波糖组(23例)、生活方式干预加用药组(21例)。生活方式干预组予以减少高热量食品的摄入,增加餐后运动量。阿卡波糖组予以口服阿卡波糖150mg/日。生活方式干预加用药组在低热量饮食的基础上口服阿卡波糖150mg/日。各组观察时间均24周。治疗前后分别再进行动态血糖检测并采用CGMS Solutions软件(MMT-7310)对动态血糖监测的数据进行分析。结果:三组治疗后24小时动态血糖平均水平、24小时动态血糖≥7.8mmol/L及≤3.9mmol/L的时间百分率与治疗前比较下降显著(P<0.05);与生活方式干预及阿卡波糖组相比,药物联合生活方式干预组24小时动态血糖平均水平、24小时动态血糖≥7.8mmol/L及≤3.9mmol/L的时间百分率的差异有统计学意义(P<0.05)。结论:药物联合生活方式干预可以减少糖尿病一级亲属发生糖尿病的风险。
Objective：To observe the glycemic excursion and intervention in the first-degree relatives of type 2 diabetes mellitus.Methods：65 cases of first-degree relatives of type 2 diabtes mellitus were randomly allocated to three groups：life style intervention group（21 cases）,acarbose group（23 cases）,the combined group（21 cases）.All were observed for 24 weeks.Before and after treatment,continuous glucose monitoring were detected and analyzed.Results：In the three groups,statistically significant differ ences were observed in levels of mean glu cose of 24-hour and the time percent in the glucose ≥7.8mmol/L and ≤3.9mmol/L（P0.05）.In the combined group,as compared with the life style intervention group and acarbose group,statistically significant differences were observed in levels of mean glucose of 24-hour and the time percent in the the glucose ≥7.8mmol/L and ≤3.9mmol/L（P0.05）.Conclusion：Acarbose combined with life style intervention reduced the risk of first-degree relatives of type 2 diabetes mellitus to be diabetes.
关键词
2型糖尿病一级亲属
血糖漂移
阿卡波糖
first-degree relatives of type 2 diabetes mellitus
glycemic excursion
acabose
