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VEGF、TNF—α、CysC、脂联素联合检测对2型糖尿病肾病患者早期诊断的观察与研究 被引量：9

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摘要 目的探讨血管内皮生长因子（VEGF）及抗体、肿瘤坏死因子-α（TNF-α）、胱抑素c（CysC）、脂联素（adiponectin）、空腹血糖（FPG）联合检测对2型糖尿病肾病患者早期诊断的临床应用价值。方法选择确诊为2型糖尿病肾病患者146例为糖尿病组同时选择40例健康正常人为对照组。应用酶联免疫分析法（ELISA）对VEGF及抗体、TNF-α、脂联素进行检测，采用日立公司7600自动生化分析仪检测CysC、FPG。结果糖尿病组VEGF、VEGF抗体、TNF-α、CysC表达显著上调，与对照组比较差异有统计学意义（P〈0．01），且与病情的进展呈正相关；而脂联素浓度明显降低，与对照组比较差异有统计学意义（P〈0．01），随病程进展血清脂联素含量呈递增趋势，脂联素与FPG水平呈负相关。结论VEGF是血管和淋巴内皮细胞的生长和分化及正常和异常血管新生的重要的调节因子，在生理和病理性血管新生中起重要作用。TNF-α是重要的炎性反应因子，与CysC、脂联素共同参与糖尿病肾病的发生、发展，联合检测有助于2型糖尿病肾病患者病情及预后的判断。
作者 孙凯
机构地区 山东省枣庄市立医院
出处 《中国实用医刊》 2013年第4期81-83,共3页 Chinese Journal of Practical Medicine
关键词 血管内皮生长因子 肿瘤坏死因子 胱抑素C 脂联素 酶联免疫分析 2型糖尿病
分类号 R692 [医药卫生—泌尿科学] R587 [医药卫生—内分泌]
  • 相关文献

参考文献5

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二级参考文献26

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共引文献134

同被引文献62

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引证文献9

二级引证文献40

中国实用医刊
2013年 第4期

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