摘要
目的:研究大剂量氨溴索对外伤所致肺损伤患者的临床疗效。方法:选择外伤所致肺损伤患者66例,随机分成常规治疗组(n=33)和大剂量组(n=33)。常规治疗组:盐酸氨溴索30mg静脉推注,2次/d。大剂量组:盐酸氨溴索450mg加生理盐水250ml,缓慢静脉滴注,2次/d,连续7d。比较两组患者在氧合、肺损伤、呼吸机辅助呼吸时间等方面的变化和差异。结果:大剂量组患者的治疗后肺损伤评分、氧合指标明显改善,与常规治疗组比较差异均有统计学意义(P<0.05或P<0.01)。呼吸机辅助呼吸时间大剂量组明显少于常规剂量组,差异有统计学意义(P<0.01)。结论:临床应用大剂量盐酸氨溴索对外伤所致肺损伤患者有明显的疗效,值得推广应用。
Objective：To investigate the clinical effect of large dose of ambroxol in the treatment of lung trauma with wound. Method： Sixty-six patients who had hmg trauma with wound were treated with ambroxol. Patients were randomly divided into general dose group （n=33） and large dose group （n= 33） according to the dosage of ambroxol. The general dose group received ambroxol 30rag iv bid for 7 days,and the large dose group received am- broxol 450 mg and 0.9 % NS 250 ml iv drip for 7 days. The changes of pulmonary oxygenation,lung injury parame- ters and duration of mechanical ventilation were monitored in the two groups. Result： The pulmonary oxygenation function and lung injury parameters in large dose of ambroxol treatment group improved significantly（P^0.05 or P〈~0.01）compared to general dose group. Duration of mechanical ventilation in large dose of ambroxol treatment group were shorter than general dose group （P% 0.01）. Conclusion： Large dose of ambroxol has obvious clinical effect in the treatment of lung trauma with wound. It is worth widespread use in clinical practice.
出处
《临床急诊杂志》
CAS
2013年第1期24-26,共3页
Journal of Clinical Emergency
