摘要
目的探讨PF诱导化疗对舌鳞状细胞癌组织中增殖细胞核抗原（Ki-67）、表皮生长因子受体（EGFR）表达的影响及意义。方法采用免疫组织化学方法检测64例舌鳞状细胞癌患者诱导化疗前后肿瘤组织中Kj-67及EGFR的表达，分析其与疗效的关系。结果诱导化疗总有效率为81．2％（52／64）。诱导化疗前Ki-67阳性者经诱导化疗的疗效明显高于Ki-67阴性者（P〈0．05），化疗前EGFR阳性者经诱导化疗的疗效明显高于EGFR阴性者（P〈0．05）。诱导化疗后Ki-67阳性及EGFR阳性患者均明显减少（均P〈0．05）。结论PF诱导化疗对Ki-67、EGFR表达有明显影响，Ki-67、EGFR的表达情况对舌鳞状细胞癌诱导化疗疗效有一定预测价值。
Objective To investigate the expressions of Ki-67 and EGFR in tongue squamous cel carcinoms treated by PF induction chemotherapy and their clinical significance. Methods Expressions of Ki-67 and EGFR were determined by im-munohistochemistry in 64 patients with tongue squamous cel carcinoma before and after PF induction chemotherapy. Results The overal response rate to induction chemotherapy was 81.2%. The response rate of patients with positive Ki-67 or EGFR ex-pression were higher than that with negative Ki-67 and Ki-67 expression before induction chemotherapy （P〈0.05）. The expres-sion of Ki-67 or EGFR were significantly reduced after induction chemotherapy （P〈0.05）. Conclusion The expression of Ki-67 and EGFR may be of predictive value for PF induction chemotherapy and inductive chemotherapy may affect Ki-67 and EGFR expression in patients with tongue squamous cel carcinoma.
出处
《浙江医学》
CAS
2012年第23期1886-1888,共3页
Zhejiang Medical Journal
