摘要
目的分析比较依赖利福平结核杆菌(依赖R菌)与耐利福平结核杆菌(耐R菌)肺结核发病特点。方法 2008年10月-2012年1月在我院住院或门诊的61例依赖R菌肺结核和148例耐R菌肺结核患者,记录人口学资料、年龄分组、抗结核药化疗史、药敏试验结果。结果(1)依赖R菌与耐R菌肺结核均以30-44岁年龄组为主;(2)依赖R菌肺结核初治12例(12/61=19.7%),复治49例;耐R菌肺结核初治11例(11/148=7.4%),复治137例;(3)依赖R菌与耐R菌肺结核发生耐多药率分别是80.3%和92.6%。结论依赖R菌肺结核患者以中青年为主,病情重。对初治肺结核治疗失败病人,检测利福平赖药性具有重要意义。依赖R菌肺结核病人,在治疗上应参照耐多药治疗方案。
Objective To compare the clinical characteristics of rifampin-dependent （R-dependent Mycobacterium tuberculosis） and rifampin-resistant （R-resistant Mycobacterium tuberculosis） patients with pulmonary tuberculosis. Methods The clinical data including the demographic data, age groups, course of disease, history of chemotherapy with anti-TB drugs, and results of drug susceptibility test were collected from 61 cases of R-dependent pulmonary tuberculosis and 148 cases of R-resistant pulmonary tuberculosis treated between October, 2008 and Januar~ 2012. Results Most of the R-dependent and R-resistant patients were between 30 and 44 years of age. The R-dependent patients included 12 receiving the first treatment patients and 49 with previous treatments, and the R-resistant patients included 11 without and 137 with previous treatments. The multi-drug resistant rate was 80.3% in R-dependent group, as compared to 92.6% in R-resistant group. Conclusion Most of the patients infected with R-dependent Mycobacterium tuberculosis are young or middle-aged, often having serious disease conditions. Detecting rifampin dependence is important for patients with initial treatment failure. Multi-drug resistance therapy guideline should be applied to patients infected with R-dependent Mycobacterium tuberculosis to improve the cure rate.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2013年第2期287-289,共3页
Journal of Southern Medical University
基金
广东省科技计划项目(20100309)
关键词
依赖利福平
耐利福平
结核分枝杆菌
肺结核
rifampin dependent
rifampin-resistant pulmonary tuberculosis
mycobacterium tuberculosis
pulmonarytuberculosis
