摘要
目的观察利多卡因对精神分裂症患者行无抽搐电休克治疗(MECT)后肌痛的影响。方法在麻醉下行电休克治疗患者60例,随机均分为两组:L组麻醉前静脉注射利多卡因40mg;N组用等容量生理盐水作为对照。麻醉采用丙泊酚1.0-1.5mg/kg和琥珀胆碱1mg/kg。MECT治疗后30min、1h和6h评估患者肌痛VAS评分。结果两组患者电击后脑电发作均超过26s。L组术后30min、1h和6h的肌痛发生率分别为50%、51%和50%,均明显低于N组的68%、68%和65%(P<0.05)。两组MECT后苏醒时间相仿[(6.5±1.7)min vs.(6.0±1.6)min](P>0.05)。L组患者苏醒后30min、1h和6h的VAS肌痛评分均明显低于N组(P<0.05)。治疗后即刻和治疗后1min,L组HR和MAP均低于N组(P<0.05)。结论静脉预注利多卡因能够降低精神分裂症患者MECT后肌痛。
Objective To observe the effect of lidocaine on succinylcholine-induced myalgia after modified electroconvulsive therapy（MECT） in patients with schizophrenia. Methods Sixty patients with schizophrenia treated by MECT were equally randomized into two groups of L（lidocaine 40mg injected before MECT） and N（normal saline injected as the control）.Anesthesia was induced with propofol 1.0-1.5mg/kg and succinylcholine 1mg/kg. MAP and HR were monitored during MECT.Myalgia after MECT was evaluated by VAS pain scoring at 30minutes,1hour and 6hours after MECT. Results The time of EEG seizure was greater than 26 seconds in both groups. The VAS scores at 30minutes,1hour and 6hour after awakening were all less in group L than those in group N（P〈0.05）.The incidence rates of myalgia at 30minutes,1hour and 6hours were lower in group L than those in group N（50%,51% and 50% vs.68%,68% and 65%）（P〈0.05）.Awakening time of group L after MECT was（6.5±1.7）minutes,which was similar to（6.0±1.6）minutes of group N（P〈0.05）.VAS myalgia scores at 30minutes,1hour and 6hours after awakening were less in group L than those in group N（P〈0.05）. Conclusion Lidocaine may attenuate succinylcholine-induced myalgia in the patients with schizophrenia after MECT.
出处
《江苏医药》
CAS
北大核心
2013年第2期176-177,共2页
Jiangsu Medical Journal
关键词
电休克治疗
利多卡因
琥珀胆碱
肌痛
精神分裂症
Electroconvulsive therapy
Lidocaine
Succinylcholine
Myalgia
Schizophrenia
